Since this is the most important step in the production of amphetamines, I have created a special section describing the preliminaries and techniques in great detail. After spending a lot of time and money to synthesize your nitropropene, you will be greatly disappointed to find that following the directions given in a journal is not enough to create an active compound. There are some minor pitfalls that many scientists figure all their readers already know about, but if they don't know about them, their reduction will fail miserably, wasting the their time and the chemicals involved.

Although many formulas listed are designed specifically for reducing to amphetamine type compounds, they should work well on other drug synthesis calling for reductions. After finding a suitable or compatible reduction formula, replace the nitrostyrene or nitropropene, etc., with an equimolar ratio of the compound you wish to reduce. If I explained everything that I would like you to know about reductions, this chapter would be about 200 pages longer than it already is; obviously I cannot say everything, so I will stick with the basics.

Reductions in organic chemistry utilizing zinc, iron, and hydrogen sulfide, have been performed since the 1840's. Catalytic hydrogenation came about in 1897, and reduction with metal hydrides came into usage in 1947.

Continue reading here: Reductions With Metal

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