Recreational Drugs Manufacture

Extracting Or Separating These Substances

A thorough knowledge of the physical properties of the compounds in the medication that you are dealing with must be known. The Merck Index will have these substances listed along with their mp, bp, and solubilities. The best way to show you how this separation is effected is to give you some examples. Let's say that I just purchased 6 fl. oz. of average codeine cough syrup. I read the label and find that every fl. oz. contains 1000 mg times 6 6000 Pseudoephedrine mg times 6 360 mg mg times 6...

LSD Synthesis

As with the rest of this book, I will deal only with the synthetic manufacture of drugs (LSD included). If you want to grow the ergot alkaloids that begin the total synthesis of LSD, then you will have to go to the Merck Index and look up the references to the operation, Michael V. Smith's book, Psychedelic Chemistry, has a section on growing Claviceps purpurea, which yield ergot compounds. This section is very complete and informative, but I think that you should also look up the dangers of...

Saturated Solutions

The following table provides the data for making saturated solutions of the substances listed at the temperature designated. Data are provided for making saturated solutions by weight (g of substance per 100 g of saturated solution) and by volume (g of substance per 100 ml of saturated solution and the ml of water required to make such a solution). To make one fluid ounce of a saturated solution multiply the grams of substance per 100 ml of saturated solution by 4.55 to obtain number of grains...

Racemic Thcs

The formulas for racemic THCs are overshadowed by the procedures above because they are not really much easier, if at all, and their yields are considerably less. If you get the formulas from a journal, remember that the yield will actually be lh. that stated. In the procedures to follow, I have figured in the yield as the actual for you. delta-3 THC. Mix 1 mole of pulegone with 1 mole of olivetol (or analog) and 0.3 mole of phosphorous oxychloride in 1000 cc of benzene and reflux for 4 hours....

LSD From Ergot Alkaloids

This was invented by Hofmann and is a superior method because you may proceed from the ergot alkaloids to LSD without isolating the lysergic acid. CA, 57,12568 (1962). Add 1.2 g of ergotamine hydrochloride to 4 ml of anhydrous hydrazine and heat 1 hour at 90 . Add 20 ml of water and evaporate in vacuo, to get d-iso-lysergic acid hydrazine. 1 g of the lysergic hydrazine is powdered well and added to 40 ml of 0.1 N (ice cold) HC1 acid. To this, cooled to 0 , is added 4 ml of 1 N Na nitrite, with...

Long Acting Barbiturates

These need to be given one hour before the effect is desired and their effect is so prolonged that you will remain drowsy the following day. Barbitone. This is also called barbital or veronol. I will start this synthesis with the intermediates (precursors) of the given formulas. Some of these formulas are given on a commercial basis and can be reduced to the size of your budget. Sodium Malonate. 100 kilos of Chloroacetic acid are dissolved in the minimum amount of cold water (this may vary, but...

Total Synthesis Of Lysergic Acid

This is the easiest way to totally synthesize lysergic acid. There are other ways, but after reviewing other methods, I found this to be superior. It is quite complicated and it takes good modern equipment. JACS, 78, 3087 (1956). 3-Indolepropionic acid, 94.5 g (0.5 mole) is dissolved in 600 ml of water containing 20 g of NaOH. The solution is mixed with 100 g of Raney Nickle catalyst and hydrogenated at room temp in a steel bomb at about 3,500 psi until the uptake of hydrogen stops (about 20-30...

LSD From Lysergic Acid Monohydrate

This is, in my opinion, the best of all the methods. It was designed to be used to experiment with different types of amines, so if you would like to substitute diethylamine with another amine this would be the best bet. It also gives good yields (50 or better) and is very easy. The reference that gives it (JMC, 16, 532 (1973)), also gives potency data for many lysergamides and many of their formulas. The reading is good, interesting, informative, and the method given below gives no useful...

Hypnotics Sedatives And Tranquilizers

The substances to be described in this chapter are those synthetic, organic compounds, which depress the central nervous system. A drug can be classed as a hypnotic, if a normal dose has the power to induce sleep. Sedatives or tranquilizers are drugs that do not induce sleep, but calm the nerves and bring about a relief of tension, hysteria or apprehension when used in normal doses. Such definitions are not rigid, since hypnotics in small doses may induce sedation and not sleep, and conversely...