and setting were not. Thus it would seen» that the "drug effect" is a delicate combination of drug plus set and setting. The drug alone is not sufficient, and positive experiences are by no means automatic. A meaningful religious atmosphere has been shown to be one setting in which positive drug experiences can occur. The religious context in our experiment appeared to give the psilocybln subjects a useful framework within which to derive meaning and integration from their experience both at the time and later. Our experience in this experiment has suggested that much forethought and preparation are needed to insure adequate set and setting although the precise qualitative and quantitative role of each factor has not been shown. For example, it must be pointed out that everything possible was done to maximize suggestion, but suggestion alone cannot account for the results because of the different experience of the control group. The hypothesis that suggestibility was heightened by psilocybln cannot be ruled out on the basis of our experiment. Although persuasive and similar to the explanation of mysticism by auto-suggestion,4 this hypothesis still needs proof. An
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