Natural Remedies To Live Drug Free

Prescription Freedom: Natural Remedies To Live Drug Free

Prescription freedom is a product that helps individuals free up themselves from drug prescriptions. It is based on ancient natural solutions and applicable to all people irrespective of age and gender. It is a product of Kevin Christianson, once a victim of drug prescriptions but now free from such chains. The ancient remedies recommended can quickly give you power and reverse any kind of illness that plagues your heart. More importantly, the program has been found to be effective even to those with difficulties in weight management, blood pressure, depression, and diabetes among other conditions. It is about natural solutions that attack your problem from the core. By means of simple booster tricks unleashed in the guide, your body will be rejuvenated to prevent the disease along with harmful bacteria from getting into your body. In case the product does not serve you as expected, feel free to claim for a refund. There is a 60-day money back guarantee and unlike other products, you will still maintain ownership of the course along with all the bonuses. More here...

Prescription Freedom Natural Remedies To Live Drug Free Summary


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Prescription Freedom: Natural Remedies To Live Drug Free

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The writer has done a thorough research even about the obscure and minor details related to the subject area. And also facts weren’t just dumped, but presented in an interesting manner.

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Classical Mandrake Prescriptions

Recreational Drugs America

The Merck Manual* on the other hand, follows a pattern _ set by the Egyptian papyri of listing various diseases, with appropriate prescriptions for each. This is also the style of the Ayurvedic medical teachings of India, which are much broader in scope. Indian medicine began in Vedic religious and magical texts of the second millennium b.c. and advanced into encyclopedias attributed to doctors Charaka and Sushruta. There is no substance in the world that is not medicine, Charaka proclaimed, and proved the point, employing thousands of drugs in prescriptions for every conceivable disease. Charaka records the world's first drug conference in the seventh century B.C., and it seems likely that his work is a compilation of all the plant lore of India at that time. Among the innovations in Charaka are recognition of about 80 varieties of wine, treating mental patients in padded cells, mantra chanting to make drugs more effective, intensive training of dancing giuls as poisoners, careful...

Prescription Drugs

Prescription drugs are drugs that the federal government has designated to be potentially harmful unless their use is supervised by a licensed health care provider, such as a nurse practitioner, physician, or dentist. Although these drugs have been tested for safety and therapeutic effect, prescription drugs may cause different reactions in some individuals.

Controlled Substances

Prescriptions for controlled substances must be written in ink and include the name and address of the patient and the Drug Enforcement Agency number of the primary health care provider. Prescriptions for these drugs cannot be filled more than 6 months after the prescription Prescription drugs, also called legend drugs, are the largest category of drugs. Prescription drugs are prescribed by a licensed health care provider. The prescription (see Fig. 1-2) contains the name of the drug, the dosage, the method and times of administration, and the signature of the licensed health care provider prescribing the drug.

Very Brief Retrospective

Drugs, especially poisons, have been around as long as animals have sought relief from physical and mental pain. Primitive humans both observed animals in their consumption of native materials and experimented themselves. Ronald Siegel in his book Intoxication (E.P. Dutton, 1989) goes so far as to postulate that the desire to achieve an altered state of consciousness is a drive we share with the lower animals. Originally steeped in magic, the human use of drugs is as old as recorded history. Egyptian medical records written on papyrus around 1500 B.C. (the Ebers Papyrus) included over 800 recipes for the therapeutic and toxic uses of such natural materials as opium, digitalis(from foxglove),heavy metals (such as lead and silver, not music), and atropine. Some of these prescriptions were effective, many were not. The ancient Romans, Greeks and Chinese used many types of drugs, herbs and drug formulations as well as poisons. Who does not know the fate of Socrates Or if you saw the PBS...

Look Back in Ananda40 Years of Research on Cannabinoids

The Assyrians, who ruled parts of Mesopotamia for centuries, left us a legacy of clay tablets with hundreds of prescriptions, nearly all of which were based on local plants. And the Egyptian papyri are a treasure trove of many yet-uninvestigated plants used in numerous medical conditions some of which, unfortunately, have no parallel in modern diagnosis. But the most valuable ancient text is undoubtedly that of Pedanius Dioscorides, a Greek physician in the Roman army during the first century A.D., describing about 600 medicinal plants of the Middle East. For over 18 centuries the Dioscorides Herbal was one of the most influential drug books (for an overview of these ancient sources see Mechoulam, 1986). Are there medicinal plants in these sources which, from the viewpoint of modern chemistry and pharmacology, have not been well investigated The answer was yes then and is still yes today. One of plants I decided to look into was Cannabis sativa.

Letter from the President and Executive Director

For the first time in a long time, we feel the momentum on drug policy shifting in our favor. The political climate is rapidly changing - at the state and local level as well as nationally. The current dialogue on drugs and drug misuse, prevention and enforcement is becoming more sophisticated. The public has grown skeptical of the drug war and politicians are figuring out that tough on drugs rhetoric is not a real solution. The Drug Policy Alliance and the growing movement in which we play a leadership role are fast maturing. The many accomplishments detailed in this report certainly point to a shift in tone and tenor.

Federal Food Drug and Cosmetics Act 1938

The foods section of the legislation sets standards for food for both humans and animals. It has three subdivisions which pertain to illegal foods, legal additions to foods(additives), and the labeling of food items. The portion governing drugs has parts pertaining to new drugs, prescription drugs, over-the-counter drugs, biological drugs, and medical devices. The third section concerning cosmetics specifies that they must be safe, labeled truthfully as to the ingredients and manufacturer's name and address, and that they must be packaged under sanitary conditions.

Drug Administration Drug overdose

A bleak picture has rapidly evolved for amoxapine with regard to its toxicity in overdosage. Over 18 months, 33 cases were reported from Washington, DC, and New Mexico Poison Centers (2). These cases included 5 patients who died and 12 who developed seizures. Thus, the mortality rate of 15 greatly exceeds that of 0.7 for other antidepressants in the same centers, and the seizure rate is 36 compared to 4.3 . The authors noted that the striking CNS toxicity of amoxapine overdose with frequent, persistent, and poorly controlled seizure activity is disconcerting.'' In a retrospective comparison of deaths from antidepressant overdosage in Scotland, England, and Wales between 1987 and 1992, the number of deaths per million prescriptions of amoxapine was significantly higher than expected (13).

Ineffective Therapeutic Regimen Management

The reasons for not following the drug regimen vary. For example, some people do not fill their prescriptions. Other patients skip doses, take the drug at the wrong times, or take an incorrect dose. Some may simply forget to take the drug others take a drug for a few days, see no therapeutic effect, and quit. Some find the adverse effects so bothersome that they discontinue taking the drug without notifying the health care provider. Display 4-1 identifies some reasons for this ineffective therapeutic regimen management.

Significant Amendments

Durham-Humphrey Act(1952) - This amendment defined specific drugs which may be supplied by a licensed pharmacist upon the prescription by a registered physician. Under this act these drug prescriptions may not be refilled unless authorized by the physician. Kefauver-Harris or Drug Amendments Act (1962) - In 1953 a small German chemical company synthesized and studied a compound which seemed to have potential in the fledgling field of sedative-hypnotic drugs. Although the drug was tested for toxicity it took several years and many thousands of prescriptions in Europe to discover that the sedative and antinausea drug, called thalidomide, caused gross malformations in growing fetuses. It should be noted that a 1939 addendum to the original 1938 legislation made testing for toxicity and teratogenicity mandatory for all new drugs. This prevented thalidomide from being marketed in the United States. As a result of the thalidomide tragedy the Kefauver-Harris Act added more provisions for...

Medicolegal Death Investigation

Police reports and investigations provide scene documentation. Typically, a report will include a description and identification of the body, time and place of death, eyewitness accounts, drugs present, and photographs. Investigators assigned by the medical examiner collect all items and information pertaining to establishing the cause and manner of death. Investigators contact the family and friends of the deceased for information regarding, for example, past medical and social history and prescribed medications. Many cases have histories of prescription drugs to guide the investigation. All medication bottles should be verified as to content and count, in addition to performing a routine pharmacy check of the person's medication usage. Medical examiner investigators must also contact hospitals and treating physicians to obtain copies of medical records and police agencies to obtain arrest records. Progressively, a file is assembled that contains all of the relevant background...

Changing State Laws From 1978 to 199512

For example, several states passed laws stating that doctors may prescribe marijuana. However, federal law prohibits doctors from writing prescriptions for marijuana, so doctors are unwilling to risk federal sanctions for doing so. Furthermore, even if a doctor were to give a patient an official prescription for marijuana, the states did not account for the fact that it is a federal crime for pharmacies to distribute it, so patients would have no way to legally fill their marijuana prescriptions.

National Drug Control Strategy Budget

In this new extension of the drug war, termed pharmacotherapy, the federal government is partnering with large and small pharmaceutical companies to develop a new breed of pharmaceutical drugs designed to padlock the brains of drug users so that even if a person ingests an illegal drug, the drug will be intercepted within the blood stream or otherwise blocked from entering the brain. The American government's hope is that demand for illegal drugs can be reduced, in part, by chemically eliminating the very desire to use an illegal drug.

Organs and Systems Cardiovascular

A retrospective study of prescriptions from three cohort studies suggested a possible adverse effect of oral bambuterol cardiac failure. A cohort of 12294 patients who received at least one prescription for nedocromil acted as the control group and was compared with 15 407 patients given inhaled salmeterol and 8098 patients given oral bambuterol. Questionnaires were sent to each prescriber asking for details of significant medical events after the first prescription (prescription event monitoring). From this information, rates and relative risks of non-fatal cardiac failure and ischemic heart disease were calculated. The age- and sex-adjusted relative risk of nonfatal cardiac failure associated with bambuterol was 3.41 (CI 1.99, 5.86) compared with nedocromil. When salme-terol was compared with nedocromil the relative risk for developing non-fatal cardiac failure was 1.1 (CI 0.63, 1.91). The adjusted relative risks of non-fatal ischemic

Medicolegal considerations

Efforts to restrict benzodiazepines in New York State (2,7) and to ban triazolam (Halcion) in the UK (7,41) and the Netherlands (42)(SEDA-4,V) have likewise been fraught with controversy. For example, the requirement to use triplicate prescription forms in New York has been effective in reducing prescription volumes, including arguably necessary and appropriate prescriptions (43). A 1979 suspension of triazolam availability in the Netherlands was overturned in 1990, while a 1993 formal ban in the UK has remained in force (44). Two extensive reports have included recommendations for resolving the special problems posed by the Halcion controversy (44,45).

Benzodiazepines Misuse patterns

A common method of getting large amounts of benzodiazepines used by addicts is to go to tens or seometiomes hundreds of physichans and obtain prescriptions for real or fake sym-potoms or to buy pills or prescriptions dirctly from medical professionals or perons wokring in the pharmacetutical industry. As computers are introduced in pharmacies and

Contamination of Herbal Drugs and Herb Drug Interactions

Conventional synthetic pharmaceuticals such as synthetic corticosteroids, nonster-oidal anti-inflammatory drugs and other prescription drugs, potent drugs such as Many people, especially those living with HIV AIDS, use both herbal medicines and prescription drugs. A number of clinically significant interactions between prescribed and herbal medicines have been identified. When these medications are used together, they can interact in the body, causing changes in the way the herbs and or the drug works. Such changes are called herb-drug interactions. Concurrent use of herbal or homeopathic remedies alongside prescribed or over-the-counter medicines are frequent, and may mimic, magnify, or oppose the effect of the drug 100 .

Labeling of Herbal Products

A herb categorized as a nutritional supplement cannot claim any health benefits or disease claims on the label, leaving the consumer with little information 137 . Marketing plays a big role in the use of herbal products and the media help significantly to provide information about natural health products. One of the problems with mass media propaganda is scientific inconsistency. Unless the packaging contains a medical claim, herbal products are not reviewed by any government agency. Food and drug administrations that regulate prescription drugs only review a herbal product if the item is suspected of being harmful or if the label contains medical claims. Scientists use several approaches to evaluate botanical dietary supplements for their potential health benefits and safety risks, including their history of use and laboratory studies using cell or animal models. Studies involving people can provide information that is relevant as to how botanical dietary supplements are used.

Terms And Names A Terms

Prescription Drug - also called an ethical drug. These medications must be prescribed by a licensed physician, dentist or veterinarian. They may be covered by a patent or be in the public domain. Nonprescription Drug - also referred to as an Over-The-Counter drug (OTC). Sometimes these materials are called proprietary but the latter term can also be applied to patented prescription drugs.

Policies and Regulations

It is important that consumers are made aware of interactions herbs might have with other drugs they are taking. Unfortunately this information is not available with herbals. Herbals are also frequently adulterated with prescription drugs. In certain countries, herbal products used for diagnosis, cure, mitigation, treatment, or prevention of disease are normally treated as drugs, and hence regulated by legislation. However, in most countries, including the United States, such legislation does not exist and in fact, most botanical products are marketed as dietary supple It is clear that the herbal industry needs to follow strict guidelines and that regulations are needed. The food and drug administrations that regulate prescription drugs only review a herbal product if the item is suspected of being harmful or if the label contains a medical claim. Although research is being done, it is very limited and only a few herbal drugs have been studied adequately by well-controlled clinical...

The Role of the English Language

It is also important to recognize the role of the English language in facilitating this inquiry. English uses the term drug ubiquitously and colloquially for all the categories of substances we are examining across the board, from prescription drugs to over-the-counter drugs to herbal drugs to religious-use drugs to sports-enhancement drugs to illegal drugs. The only exception In contrast, this inquiry will seem more difficult conceptually in many other languages. Dutch, for example, has no word for drug that is used across the board it uses drog only for illegal drugs, subdividing them into hard drugs (e.g., heroin) and soft drugs (e.g., marijuana). Dutch uses medicijn (from the French, m decine) for pharmaceutical drugs or Geneesmeddel, literally healing substances. Most languages involved in Olympic sports use the term doping (a term from South Africa) for sports-enhancement drugs the United States adopted this term at a comparatively late point. German uses Droge (drug) and also...

Nonbiological Evidence

Evidence found at a scene may provide additional information to assist in the toxicological investigation. Drug paraphernalia (cocaine spoons, cookers, bhongs, syringes, poppers, whipped cream propellant canisters, butane lighters, etc.) is suggestive of a possible drug-related death, or at least a history of drug abuse. Prescription drugs at a scene may be useful for compiling a list of suspected drugs, attending physicians, and pharmacy phone numbers. However, this evidence may be misleading as drugs found at a scene are frequently old, may not have been taken for years due to patient compliance problems, or may be someone else's medication. Pain medication and tranquilizers, particularly important in drug deaths, are often prescribed to be taken on an as-needed basis, and thus subject to collecting in medicine cabinets. Counting the number of tablets or capsules

Trends in drug use among young people what do we know

The overall decline in illicit drug use among young people in the United States and in some European countries is an encouraging sign. However, there are a number of published reports, particularly in the US indicating that the abuse of prescription drugs is on the rise among young people10. This needs more research, but these reports suggest that young people may be shifting from illicit drugs to pharmaceutical drugs, which may be more easily accessible and socially acceptable. 10 Arria AM, Caldeira KM, O'Grady KE, Vincent KB, Johnson EP, Wish ED. Nonmedical use of prescription stimulants among college students Associations with attention-deficit-hyperactivity disorder and polydrug use. Pharmacotherapy. 2008 28(2) 156 169. National Institute on Drug Abuse (NIDA), NIDA Community Drug Alert Bulletin Prescription Drugs, NIDA website http www.nida. PrescripAlert .

Prescription Pharmaceuticals and Overthe Counter Drugs

Still, there was no requirement for a prescription for any drug other than those defined in the 1914 Harrison Narcotics Act. In 1951, however, the Durham-Humphrey Amendment20 to the Food, Drug, and Cosmetic Act required both proof of safety for drugs and their classification either as over-the-counter or prescription only, creating a mechanism for deeming drugs as requiring a prescription when they could not be used safely without the supervision of a physician. Over the next decades, several other developments contributed to the evolution of regulations governing drug products. These included the Kefauver-Harris Drug Amendments of 1962, which required not only that drugs be proven safe but also effective. Problems arose, however, with regard to drugs that were grandfathered in under the regulatory scheme, as obtaining data on safety and efficacy proved difficult after the drug was already on the market. To deal with these difficulties and appropriately implement the law, several...

W Hemp Chronicles

End, it argues that cannabis has far fewer side effects than most of the prescription medications available on the market, and is fundamentally harder to overdose on given the incredibly enormous LD-50 of THC. Many in the medicinal community regard the scheduled nature of cannabis as ludicrous in Treating Yourself issue 10, writer Wendal Grant compares the enormous and incredibly daunting list of side-effects for the pharmaceuticals prescribed by doctors, with the comparatively-harmless effects of cannabis (Grant 2007). From this emerges the moral claim medicinal cannabis users are able to make given that the professional consensus is perceived to have a credibility gap while simultaneously claiming that a plant with no overdose or physical addiction potential and incredibly benign side-effects is an enormously harmful drug (even while the patient is experiencing relief from it), the patient is forced into a moral quandary. He or she is thus forced to either violate professional...

Moving to Crush Dissent

* Why, you ask, was the AMA now on Anslinger's side in 1944-45, after being against the Marijuana Tax Act in 1937 Answer since Anslinger's FBN was responsible for prosecuting doctors who prescribed narcotic drugs for what he, Anslinger, deemed illegal purposes, they (the FBN) had prosecuted more than 3,000 AMA doctors for illegal prescriptions through 1939. In 1939, the AMA made specific peace with Anslinger on marijuana. The results only three doctors were prosecuted for illegal drugs of any sort from 1939 to 1949.

Its getting harder every day

Blindness if left untreated and that these men were not usually being effectively treated for the causes of their dysfunction, just for the dysfunction itself. It is also true that many Viagra prescriptions were being handed out for recreational use so that men could have sustained erections. This again ignores the fundamental danger of taking any prescription medication, but erectile dysfunction drug sales have skyrocketed because of this off-label recreational use.

Long Term Effects Drug abuse

The Swiss government has developed a program called PROVE, which provides prescriptions of injectable opioids for the treatment of heroin-dependent patients. This program has generally been viewed to be successful in terms of retention in treatment, morbidity and mortality, legal behavior, and cost-effectiveness. However, during the 26-month observation period, epileptic seizures occurred in 11 of the 186 patients treated. This finding, along with previous reports of reduced regional blood supply to the brains of opioid users, led the authors to study cerebral deoxygenation after intravenous opioid administration in ten opioid-dependent subjects and to compare it with intravenous saline in ten matched controls using Near Infrared Spectroscopy (NIRS) (28). Heroin and methadone produced a rapid and dramatic reduction in both respiratory rate and cortical hemoglobin oxygenation, while saline had no effects. The authors suggested that opioid-induced acute deoxygenation of cortical...

The Federal Regulatory Agencies

The FDA is responsible for protecting the public health by assuring the safety, efficacy, and security of human and veterinary drugs, biological products, medical devices, the food supply, cosmetics, and products that emit radiation. Its code is the Food, Drug and Cosmetic Act of 1938, but it also enforces the provisions in dozens of other laws, including the Controlled Substances Act, the Dietary Supplement Health and Education Act (DSHEA), and the Prescription Drug User Fee Act. A primary duty of the FDA is to approve prescription drugs and OTC medications, and to maintain and enforce drug manufacturing standards. A prescription drug begins its journey toward FDA approval as an Investigational New Drug shown to be safe in animals and to hold promise for human studies. In humans, the drug is then tested for adverse effects in a small number of healthy volunteers (Phase I). At this point, studies also evaluate the dosage, frequency of administration, and factors that might affect a...

Selective serotonin reuptake inhibitors SSRIs

In a population-based cohort study from Denmark on women who filled prescriptions for SSRIs from 30 days before conception to the end of the first trimester, an increased risk of congenital malformations (RR of 1.84 CI 1.25-2.71) was found among women with prescriptions during the second or third month of pregnancy. There was no evidence that the association was specific to particular malformations (Wogelius 2006).

General adverse effects

In a study using the UK General Practice Research Database to determine rates of drug-induced, rare, serious adverse effects on the liver, kidneys, skin, or blood, occurring within 45 days of completing a prescription or refill in 54 803 users of either fluconazole or itraconazole, three had illnesses for which a fluconazole-induced cause could not be ruled out one with thrombocytopenia, one with neutrope-nia, and one with an abnormal liver function test just after receiving fluconazole (31). The rates were 2.8 100 000 prescriptions (95 CI 0.8, 10) for serious, adverse blood events and 1.4 100 000 prescriptions (95 CI 0.25, 8.2) for serious, adverse liver events. These results suggest that fluconazole does not commonly have serious adverse effects on the liver, kidneys, skin, or blood.

Second Generation Effects Teratogenicity

However, teratogenic effects have not been found in humans. The risk of malformations and other outcomes in children exposed to fluconazole in utero has been examined in 165 women who had taken fluconazole just before or during pregnancy, mostly in the form of a single dose of 150 mg to treat vaginal candidiasis (58). Birth outcomes (malformations, low birth weight, and preterm delivery) were compared with the outcomes among 13 327 women who did not receive any prescriptions during their pregnancies. The prevalence of malformation was 3.3 (four cases) among the 121 women who had used fluconazole in the first trimester, and 5.2 (697 cases) in offspring to controls (OR 0.65 CI 0.24, 1.77). The risks of preterm delivery (OR 1.17 CI 0.63, 2.17) and low birth weight (OR 1.19 CI 0.37, 3.79) were not significantly increased in association with fluconazole. Thus, the study showed no increased risk of congenital malformations, low birth weight, or preterm birth in offspring to women

Drug Administration Drug formulations

In the course of 1982, serious suspicions arose that this was indeed happening. In August, the UK's Committee on Safety of Medicines (CSM) stated that it had received 200 reports of adverse reactions to the product, which was considered a relatively high reporting level for a new drug, though more than 400 000 prescriptions had been issued over the previous 7 months. Many of the reports were of effects traditionally associated with indometacin (such as headache and gastrointestinal problems) and these did not seem to be less frequent with the new system. Two of the reports were of intestinal perforation distal to the duodenum, an unusual site for damage by

General Information

Pulmonary delivery of drugs is the administration route of choice in respiratory diseases such as chronic obstructive pulmonary disease and asthma. Different devices are available, including metered-dose inhalers, dry powder inhalers, and nebulizers, and nearly 80 of asthmatic patients worldwide use metered dose inhalers (1). Chlorofluorocarbons have been used as an aerosol pro-pellant in metered-dose inhalers however, they deplete the ozone layer and are being replaced by more environment-friendly propellants, even though the contribution of aerosols of this type to the total global burden of chlorofluorocarbons is less than 0.5 . The first chloro-fluorocarbon-free metered-dose inhaler for asthma treatment was approved by the FDA in 1996 (2) and the European Union has set 2005 as a target date for the withdrawal of all chlorofluorocarbon-based inhalers (1). In the USA, prescriptions for chlorofluorocarbon-free medications rose from 16.4 million in 1996 to 33.8 million in 2000 (2)....

Safety First Keeps Growing

DPA launched a redesigned website for its San Francisco-based Safety First Project, which provides strategies for parents and educators to protect teenagers from drug misuse. The revamped website,, connects parents, educators and teenagers to resources like our seminal publication, Safety First A Reality-Based Approach to Teens and Drugs. To date, more than 200,000 copies of this booklet, revised and re-released this year, have been distributed worldwide in eight languages, most recently Czech.

Ritalin Abuse The Real Paradox

Although addiction in children who take low-dose Ritalin pills orally and in a medical context is not common, this does not mean that Ritalin cannot be abused. Of all prescription drugs, Ritalin is the first choice of abuse on college campuses. Its availability, low price, and familiarity may contribute to its popularity.

DEA to Control Pharmaceuticals

The federal Court of Appeals in Boston lias granted the Drug Enforcement Administration (DEA) the authority to control prescription drug manufacture under the Controlled Substances Act of 1970. The agency had ordered manufacturers, to reduce by 6l6kilograms the amount of phenmera2ine (Preludin), a widely used diet pill. In rg.ling against the manufacturer, Ciba-Geigy Corp., the court gave the DEA the power to set manufacturing quotas for drugs it feels are being extensively diverted to the illicit market.

Ritalin in the United States

Children take it under doctors' orders to stop fidgeting and pay attention. College students snort it to get high or cram for finals. In one case, Ritalin is considered a prescription drug, and its use is medically sanctioned. In the other, it is called a drug of abuse, and its use is a felony. However, the distinction between use and abuse is not always clear.

Computerized Drugstores

The Drug Enforcement Administration has nabbed a couple dozen pharmacists and doctors, for illegal drug distribution as part of a pilot project testing the use of compulers for drugslore recordkeeping. Project DART (DAWN ARCOS Registrant Targeting) is composed of a network of computer terminals in pharmacies in the Watts district of Los Angeles that feeddala to a central computer in the Chades R, Drew School of Medicine in Los Angeles. DEA agents can thus gel a prinl-oul of all prescriptions issued for Schedule in, IV and V medications written wiiliin a given period. Any doctor, druggist or customer who has dealt in suspicious quantities of any such substance can then be investigated by the agency ARCOS (Automated Records and Consummated Otders) bureau. For news of the street trade in boodeg prescription drugs, the DEA currently relies 011 lips from 1,300 hospitals, drug crisis centers and medical examiners participating in yel another alphabet-soup bureau, Project DAWN Drug Abuse i...

Cannabinoid research today and tomorrow

Today, the United Kingdom is perhaps the leader in researching cannabinoid therapeutics. GW Pharmaceuticals is conducting large clinical trials that meet FDA prescription drug-development protocols. By developing non-smoked cannabinoid-based medicines, GW Pharmaceuticals is rapidly expanding the therapeutic application of Cannabis. According to GW Pharmaceuticals From illegal plant to prescription medicine, D. Hadorn, First Clinical Conference on Cannabis Therapeutics, Iowa City, Iowa, 2000, written materials.

History of the Regulatory Approval

The process of drug approval underwent an evolutionary change throughout the 20th century (20, 21). Major changes are invariably triggered by some public health hazards. The first major piece of legislation at the beginning of this century was the 1906 Pure Food and Drug Act, which mandated that the labeling on the package be truthful. There was no requirement for safety and efficacy as we know today. The New Drug Application (NDA) process did not begin until the passage of the original 1938 Federal Food, Drug and Cosmetic (FD& C) Act, which only demanded that the manufacturer submitted an NDA with safety data before marketing a new drug. The manufacturer could market the product if the FDA had no objection to the NDA within 60 days. It was up to the manufacturer to decide whether or not the new drug would be prescription or OTC. The distinction between prescription drugs and OTC drugs is based on the Durham-Humphrey amendment in 1951, which limited the following three...

Part of the Problem The Miscategorization of Drugs within the Regulatory Framework

It is one thing, however, to remark that drug policy conforms to the framework of prescription legend and controlled-substance Schedules in theory, and quite another to observe whether it does so in practice. Clearly, there are bizarre discrepancies between the theoretical framework and the way in which specific drugs are categorized. These discrepancies account for many of the inconsistencies in policy outlined in the earlier chapters of this book, and they are a major source of disagreement in public discussion in all areas across the board. Many of these questions have already been asked. Why, for instance, is heroin classed as Schedule I but morphine as Schedule II despite their functional equivalence How can ephedra, when marketed as a dietary supplement, remain essentially unregulated, while its active ingredient, marketed as the medication ephedrine, is a fully regulated prescription pharmaceutical And how can we reconcile the fact that in one case, that of the prescription...

Lone Star DMen Follow DEA Script

New DEA guidelines for spotting forged prescriptions are being used by a Fort Worth, Texas, script detail * D-man L. D. Ansley says the crackdown has led to revocation of some druggists' licenses for failing to check suspicious prescriptions. Demerol and morphine top the forgers' hit parade. The DEA says tip-offs include legible handwriting, unusual dosages or directions, lack of proper abbreviations, textbook language and photocopied forms. The agency advises pharmacists to check both doctor and patient on all prescriptions written on hospital blanks, since these are easier to pilfer than are forms from doctors offices.

Second Generation Effects Pregnancy

There has been a study in a Danish county (population about 490 000), including data on all women who between 1991 and 1998 had a live birth or a stillbirth after the 28th week of gestation, or who had a miscarriage (including missed abortions) (221). The researchers performed a case-control study using data from the Danish birth registry, the county hospital discharge registry, and the county's prescriptions database. The risk of miscarriage was examined. The study involved 4268 women who had had their first miscarriage, 63 of whom had filled a prescription for an NSAID in the 12 weeks before being discharged from hospital after the miscarriage, and 29 750 primiparous controls who had live births. There was a significant association with miscarriage both when the prescription for the NSAID was filled during the week before the miscarriage (OR 7.0 CI 2.8, 17) and when it was filled at 7-9 weeks before the miscarriage (OR 2.6 CI 1.8, 4.0).

Images of Alcohol and Drug Addiction in the General Population Stigma Social Support and Change Optimism

As the preceding quotes from the SINR study illustrate nicely, lay theories on addiction are by no means simplistic. The representative survey confirms this by revealing that two-thirds of the population think the chances for self-change depend on the substance to which the person is addicted. This should not come as a surprise if one thinks about the diverging images of licit and illicit drugs in the public arena transmitted by the media. That is, when presented with a list of various addictive behaviors and asked to rate the chances of natural recovery, respondents are more optimistic about self-change from smoking tobacco and cannabis (attributing about a fifty-fifty chance) than about spontaneous remission from hard drugs such as heroin and cocaine (only in approximately 13 of the cases do they see this as a possibility). Men tend to be more optimistic than women, except for the consensus on hard drugs and prescription drugs, in which no significant differences were detected....

Refining the amphetamine test

Prior to the issue of doping becoming a major public issue, indeed from 1958, Professor Arnold Beckett and his colleagues at the Chelsea College, London, had been working on methods to find trace amounts of drugs and metabolites in biological fluids. In March 1965 they presented a paper focusing on amphetamines at the International Research Symposium on Medicinal Chemistry at Chelsea College. During the conference, Beckett was approached by a Belgian scientist, Dr Paul Janssen, who was interested in sports applications. The key elements were timing and reliability. Janssen was apparently encouraged when Beckett told him the results could be known in 48 hours. Beckett later reported that Janssen's idea was to 'notify sports authorities of our important sensitive methods because in many countries a very serious problem of drug misuse in sport was developing' (Beckett 1986 564). It became clear that the techniques being implemented by Venerando and colleagues in Italy, and Dumas and...

Case 3 Prescription vs Overthe Counter DrugsIs the Difference Due to Safety or to Profit

In 2003, the pharmaceutical manufacturer AstraZeneca requested and obtained approval from the FDA to change its prescription heartburn medication, Prilosec, to over-the-counter status. This change was requested at the time the patent for Prilosec was about to expire. Simultaneously, AstraZeneca introduced a new prescription drug, Nexium, which is therapeutically comparable to Prilosec, although with a slightly different dosing format. Is this a legitimate medical distinction between a prescription drug and a nonprescription drug Case 3 Over-the-counter (OTC) drugs are deemed acceptable for medical use without the necessity of monitoring by a health professional. OTC drugs must contain labeling that is appropriate for use by non-clinicians (so-called lay persons) and include adequate instructions for use, including dosing and precautions. Some medications are available in lower strengths as OTC medications, such as ibuprofen 200 mg tablets (e.g., Advil) and in higher strengths as...

George Bush doesnt care about black people

Within the ranks of Republican legislators. The simple idea was quite good - expand prescription drug coverage to seniors. That alone brought many people on board, but it got ugly when the details were allowed to trickle out. First, the act resulted in a 17.4 increase in premiums for people enrolled in Medicare, the largest increase ever. The administration was careful to release this information on a Friday afternoon before a holiday weekend to lessen the blow. If that were the only problem with the passing of this law, I might argue that it was an essential part of increasing coverage. But it wasn't. involved in billing for health services to understand. Before the program went into effect, Medicare Prescription Drug Discount cards were made available to seniors by private companies. But these cards were fraught with fraud and were inexplicably complex to navigate, so only about 19 of eligible people actually signed up. Leading up to the implementation of the prescription drug...

The Oxy Contin Controversy

Should Purdue Pharma continue to manufacture and distribute OxyContin, given its high potential for abuse In recent years, the preparation of oxycodone marketed under the brand name Oxy-Contin has become a favorite of opioid abusers, replacing heroin in many states. Along with the increase in abuse, there have been many overdose fatalities. Some commentators have argued that OxyContin is a more insidious drug than heroin because it is obtained more easily from diverted prescriptions and does not have the risks of adulteration that are characteristic of heroin. Others point out that precisely because it is manufactured under strict controls, it is to be preferred to street heroin. for 2006 found that in parts of Europe, Africa, and South Asia prescription drug abuse has already outstripped many illegal drugs, including heroin, cocaine, and Ecstasy.16 Still others suggest that OxyContin has become a gateway drug both a drug of abuse in itself and a lead-in to other drugs from illicit...

Pyrimethamine sulfadoxine

Pyrimethamine 25 mg plus sulfadoxine 500 mg is available in the combination formulation known as Fansidar. This combination, while effective in the prevention and treatment of Plasmodium falciparum malaria, carries a high frequency of adverse effects hematological and serious skin reactions occur, but there are also reports of polyneuritis, vasculitis, and hepatotoxicity. Most of the severe skin reactions and the cases of vasculitis developed within under a month (SEDA-13, 812). The use of Fansidar for malaria prophylaxis has therefore been virtually abandoned (SEDA-21, 297). However, Fansidar is being increasingly used for the treatment of P. falciparum malaria in Africa. With the higher dosage used for that purpose, an increase in adverse effects, particularly hemato-logical, can be expected. In Britain the retrospective reported rate for all serious reactions to Fansidar was one in 2100 prescriptions and for skin reactions one in 4900 prescriptions, the death rate being one in 11...

Case 7 Drug Interactions between Prescription and Alternative Medications

John's wort has shown efficacy against mild to moderate depression in some but not all clinical trials. The hypothesized mechanism of action overlaps with that of prescription medicine, calling into question the classification of St. John's wort as a dietary supplement and not a drug. This plant is also known to stimulate enzymes in the body that normally metabolize both Cyclosporin A and many other important medications, including warfarin, digoxin, irinotecan, indinavir, carbamazepine, fluoxet-ine, simvastatin, and oral contraceptives. When metabolism is stimulated, these drugs are cleared more rapidly, producing a drop in blood levels a so-called drug interaction. No such information or warning is provided on the St. John's wort label, as would be required for prescription or OTC preparations. Even though Mary Jo carefully researched the clinical evidence and the products and followed the instructions, a drastic and very

Observational studies

In a Prescription Event Monitoring study of the safety of risperidone in 7684 patients treated in general practice, information on risperidone prescriptions issued to patients in England was gathered between July 1993 and April 1996 (10). After 6 months, 76 of the patients for whom data were available were still taking risperidone. Drowsiness sedation was the most frequent reason for stopping risperidone and the most frequently reported event (4.6 cases per 1000 patient-months). Extrapyramidal symptoms were rarely reported, the incidence being 3.2 per 1000 patient-months they were more frequent in elderly patients (7.8 per 1000 patient-months). There were only four reports of dyskinesias and one report of tardive dyskinesia, which resulted in withdrawal of risperidone. Eight overdoses of risperidone alone were reported, with no serious clinical sequelae. Nine patients took risperidone during ten pregnancies, with seven live births and three early therapeutic terminations. There were...

Memorandum from Release

The Advisory Council on the Misuse of Drugs (ACMD) is the statutory body which advices the Government on issues relating to drug misuse. The ACMD derives its power from section 1 of the Misuse of Drugs Act 1971 (MDA 1971). The MDA 1971 states The ACMD should also advise on measures which should be taken in relation to preventing misuse of drugs or dealing with the social problems connected to drug misuse. Section 1(2) of the MDA 1971 provides for particular circumstances where measures should be applied. In relation to classification of drugs the ACMD have a statutory duty to consider measures which would restrict the availability of drugs which they consider harmful. The Research, Statistics, Development branch of the Home Office commissions and publishes research into issues surrounding drug misuse. As previously mentioned, the ACMD is required to keep up to date on issues relating to drug misuse. It is their involvement in the drug policy process which ensures that evidence is re...

Misuse and dependence

More than 200 billion in prescription and OTC drugs are produced each year in the United States. According to a 2005 study by the National Center on Addiction and Drug Abuse (NCADA), OTC and prescription drug abuse almost doubled between 1992 and 2003. Abuse among teens more than tripled during that same period. Addiction rarely occurs among people who use pain relievers, central nervous system depressants, or stimulants as prescribed. However, inappropriate use of prescription drugs can lead to addiction. In addition, the amphetamines found in many diet pills have been tied to the development of anorexia nervosa, a disease associated with extreme dieting and excessive thinness. Many medications contain alcohol or sedative drugs such as codeine, which can be addictive and life threatening. Young people may abuse these medications for the effects derived from alcohol use, as the alcohol content in some OTC preparations may be as high as 40 percent. In addition, the use of alcohol, a...

Electrolyte balance

However, since the publication of RALES the incidence of hyperkalemia attributable to spironolactone has increased. Trends in the rate of spironolactone prescriptions and the rate of hospitalization for hyperkalemia in ambulatory patients before and after the publication of RALES have been examined in a population time-based series analysis (2). Among patients treated with ACE inhibitors who had recently been hospitalized for heart failure, the spironolactone prescription rate increased immediately after the publication of RALES, from 3.4 in 1994 to 15 in late 2001. The rate of hospitalization for hyperkalemia rose from 0.2 in 1994 to 11 and the associated mortality rose from 0.3 to 2.0 per 1000 patients. These increases were particularly marked in elderly people.

Problem Substance Use and Substance Related Harm

Source Information Centre, Lifestyle Statistics, Statistics on Drug Misuse England 2007 (London, England National Health Service, 2007), p. 10. 3. To obtain a national estimate of the prevalence of problem drug misuse in the year 2003, we have summed the local estimates for each of the 32 Council areas in Scotland. On this basis, we estimate that there are 51,582 individuals who are misusing opiates or benzodiazepines within Scotland. The 95 confidence interval attached to this estimate is 51,456 to 56,379. This corresponds to a prevalence rate of 1.84 of the Scottish population aged between 15 and 54 (95 CI 1.84-2.01 ). As noted in the methods section the 95 confidence is skewed as it is derived from combining the distributions of the stratified estimates, which are themselves skewed.

Drug Administration Drug dosage regimens

Benzodiazepine prescribing for sleep induction in an elderly medical inpatient population has been examined, to determine if hospital prescribing increases the use of benzodia-zepines after discharge (5). The secondary objectives included monitoring for adverse effects and assessment of the quality of sleep in hospital compared with the quality of sleep at home. Inpatient and outpatient prescribing of ben-zodiazepines used for insomnia was recorded over 3 months. Benzodiazepines were prescribed for 20 of patients, and 94 of the prescriptions were for temazepam. Of the 57 patients who were given benzodiazepines during a hospital admission, 57 had not taken a benzodiazepine at home before admission. Benzodiazepines were effective in the short-term for inducing sleep in hospital, with little evidence of adverse effects.

A critique of elite sport

The early discourses on anti-doping, from the mid 1950s onwards, can be interpreted in a number of ways. They may be an overinflated attempt to moralise and establish control over sport and over deviant sections of society. They may be a projection on to sport of middle-class anxieties about drug misuse, sexual profligacy, political radicalism, and cultural decadence. They may represent a clash of cultures between generations the pre-war sober, austere, amateurs up against the progressive nationalistic, professional and scientifically inclined post-war innovators. These are interconnected and each a partial explanation. However, just as interesting was the manner in which sport itself came under discussion around that period in a way that rarely occurred from the 1970s onwards. The ideology underlying elite competitive sport is now a consensus, and any one who challenges it will probably be dismissed as a neo-Marxist, wishy-washy liberal, or jealous failed athlete.

General Properties and Classification of Phytocompounds

Plants have become increasingly important as a source of biologically active natural products. It is estimated that 25 of all medicines contain plant derivatives, and plant components have been used as the starting material for many semi-synthetic drugs 8, 9 . Herbs are often considered to be safer, gentler, and of lower cost than conventional pharmaceutical drugs. Plants are efficient chemical factories that produce a wide variety of chemical compounds called phytochemi-cals. Phytopharmaceuticals are complex products, and their inherent biological variation is due to different growth, harvest, drying, and storage conditions 7 . There was a big upsurge in the popularity of complementary and alternative medicine (CAM) in the United States in the 1990s. A survey showed that use of herbal medicines increased from 2.5 in 1990 to 12.1 in 1997. The usage of CAM is generally more frequent among women and people in the 35-49 age groups 5, 10 . In the western United States research...

Analytical True Positive Versus Clinical False Positive

Healthcare providers who make clinical or management decisions based on drug test results do so because of the confidence they have that a positive result confirmed by the laboratory is a true positive. But a confirmed positive result is only an analytical true positive, while it can be a clinical false positive. This is because the presence of a drug or drug metabolite in the urine documents only that the individual has been exposed to the drug but warrants no inference about the nature of the exposure or the reason for the positive test. The person may very well have a valid explanation for producing the positive drug test, for example, he or she is on a prescription medication containing codeine, which can account for the positive codeine and morphine results. In the context of the reason for drug testing, this analytical true positive result may wrongly implicate the person as an illicit drug user. Hence, this gas chromatography-mass spectrometry (GC-MS) confirmed analytical true...

Supplementary memoranda from the Advisory Council on the Misuse of Drugs ACMD

Drug misuse is one of the major social, legal and public health challenges in the modern world. In the UK, the total burden of drug misuse, in terms of health, social and crime-related costs, has recently been estimated to be somewhere between 10 billion and 16 billion per year (Ref 1). The main current approaches to drug misuse are interdiction of supply (via policing and customs control), education and treatments. All three demand clarity in terms of the relative risks and harms that drugs engender. At present, attitudes to policing and the punishments for possession and supply of drugs are scaled according to their classification under the Misuse of Drugs Act (MDAct), while education and health care provision are nominally tailored to the known actions and harms of specific drugs.

Teens and Antidepressants

The previously mentioned survey indicates that a vast majority of depressed adolescents never receive treatment for their illness, yet the number of antidepressant prescriptions written for teens increases every year. A pediatric survey conducted in the years 1995 and 1999 found the number of adolescents prescribed Prozac-like drugs increased 78 percent. In the 7-12 age group, prescriptions increased 151 percent for kids age 6 and under it rose to a surprising 580 percent. For children under 18, the use of mood stabilizers other than lithium has increased 40-fold, or 4,000 percent, and

Opium thebaicum Opium

Ovaribran Drug containing more than one substance whereof one under international control Oxazepam. Ovartone Amobarbital. Over the hump Colloquial term for having past the peak of a drug effect. Over the lump Colloquial term for having past the peak of a drug effect. Over their cups Colloquial term for discussion conducted while drinking. Over-the-counter (OTC) See Pharmaceutical drug.

Abu Ali alHusayn ibn Abdallah ibn Sina See Avicenna

In DSM-IIIR, psychoactive substance abuse is defined as a maladaptive pattern of use indicated by continued use despite knowledge of having a persistent or recurrent social, occupational, psychological or physical problem that is caused or exacerbated by the use or by recurrent use in situations in which it is physically hazardous. It is a residual category, with dependence taking precedence when applicable. The term abuse is sometimes used disapprovingly to refer to any use at all, particularly of illicit drugs. Because of its ambiguity, the term is not used in ICD-10 (except in the case of non-dependence-producing substances, see below) harmful use and hazardous use are the equivalent terms in WHO usage, although they usually relate only to effects on health and not to social consequences. The Office of Substance Abuse Prevention in the USA has also discouraged employment of the word abuse, although terms such as substance abuse remain in wide use in North America and in...

Miristilbencilmorfina Myrophine Mirsol Zipeprol

Mister Natural Colloquial term for LSD. Mister blue Colloquial term for morphine. Mistle-hal Phenobarbital. Misuse, drug or alcohol Use of a substance for a purpose not consistent with legal or medical guidelines, as in the non-medical use of prescription medications.The term is preferred by some to abuse in the belief that it is less judgemental. See also Hazardous use Miswada Colloquial term for a person who smuggles drugs in the anus. Mitchaphen Phenobarbital. Mitex Drug containing more than one substance under international control Phenobarbital.

The Toxicology Examination

Occasionally, mere detection of a drug is sufficient. But, in the case of some prescription medications, the actual amount present must be quantified. A request for therapeutic drug analysis may be made even if the autopsy has already determined the cause of death. If a history of seizure is obtained, the pathologist may request an antiepileptic drug screen to determine whether or not the person was taking any such medication. The same holds true for, e.g., theophylline in individuals with asthma. An individual who has committed suicide may have been prescribed therapeutic drugs for depression or other mental illness. A test for these drugs may indicate the degree of patient compliance. In forensic toxicology, a negative laboratory result carries the same weight as a positive result. 4. Does the evidence indicate if a substance was taken for therapeutic purposes, as a manifestation of drug misuse, for suicidal purposes, or was it administered homicidally

Substances Known to Metabolize to Methamphetamine and Amphetamine

Many medications and substances are known to metabolize to methamphetamine or amphetamine, thus giving analytical true positives (Table 2). If a patient is on one of these medications, the positive result is a clinical false positive. Enantiomeric analysis may be useful in verifying that the positive result was due to the use of a prescription drug. For example, selegiline, a drug used in the treatment of Parkinson's

Tables of equivalency of selected psychiatric drugs

Influenced by the fact that their numerous ills lead to the accumulation of prescriptions for different types of medications. Drugs are added to this list more often than they are removed removal is often stubbornly resisted by patients because of the false security medicaments may provide.

Extemporaneous Preparations Containing Cocaine

There are no prescription medications that contain cocaine. Extemporaneous preparations containing cocaine, however, are used as local anesthetics in ENT surgery and in ophthalmological procedures. Patients who had had these ENT and ophthalmo-logical procedures tested positive for benzoylecgonine up to 2-3 days following the procedure (9,10).

OTC Classification in Japan

Drugs in Japan are classified into prescription, non-prescription (OTC), and quasi-drug. Prescription drugs are those drugs that require physician supervision (50-53). Non-prescrip-drugs are primarily for mild actions and are only available in the pharmacy or drug store. Deregulation reform reclassified 15 categories of non-prescription drugs to create a new class of drugs called quasi-drugs, which can be sold in convenience stores and supermarkets starting in Spring 1999 (51). Quasi-drugs are primarily used for external uses or preventive purposes. They include the popular tonic drinks, which are unique to the Japanese OTC market. All three classes of drug are regulated under the Pharmaceutical Affairs Law administered by the Ministry of Health and Welfare. Prescription drugs and quasi-drugs are approved by Ministry of Health, Labor, and Welfare (MHLW) only, whereas non-prescription drugs are approved by both the MHLW and local prefectural governments. OTC drugs are approved by...

Determination of Other Cannabinoids in Urine

GC MS analysis for acid (THCVA) has been used to determine whether the presence of THCA in a subject's urine indicates the use of marijuana or is solely the result of the use of the prescription drug Marinol (synthetic THC ref. 40). A9-Tetrahydrocannabivarin, a homolog of THC, is present in most marijuana and is metabolized in the body to THCVA (41). Because THCVA is a homolog of THCA, the two compounds behave very similarly during extraction and derivatization but have different retention times and form abundant ions that differ by 28 amu (40).

Goz kapagi cikarilari Turkish colloquial

Egyptian pharaohs, his admirers called him Captain Trips. Grateful Dead where infamous for there acid-tests where the audience were given (the then still legal) LSD. Their fans are called Dead Heads.McKernan died of liver cirrhosis from alcohol and drug misuse 1973. Jerry Garcia died 1997 in complications of drug abuse.

Memorandum from the Multidisciplinary Association for Psychedelic Studies MAPS

This submission comes from the Multidisciplinary Association for Psychedelic Studies (MAPS), a United States nonprofit organization whose mission is to develop Schedule I substances that may have medical or psychotherapeutic benefits into prescription medicines. This mission has made us familiar with the process in the United States for gathering scientific evidence relating to the classification of illegal drugs, 2. In the United States, the process for gaining the necessary permissions to conduct scientific research using currently prohibited substances is different for cannabis than for other Schedule I substances such as MDMA, LSD, or psilocybin. Despite broad interest among United States citizens and State governments, the process for conducting research into the medical uses of cannabis is seriously obstructed. This submission will first share information about the research requirements for substances other than cannabis, followed by a description of MAPS' experience with the...

CH2CNH2 stimulatory activity

Phenylalkylamine Spirits

Added to these terms should be another - drug abuse. Drug abuse, also called chemical or substance abuse, has a definition dependent upon societal norms. It is the use of agents to the extent that they interfere with the health and normal social functioning of the individual (Cocaine, Marijuana, Designer Drugs Chemistry, Pharmacology, and Behavior CRC Press 1989). This is not to be confused with drug misuse which can mean using a drug for purposes other than prescribed or in amounts other than prescribed. The AMA, when defining drug use versus abuse points out that it is crucial to consider the nature and amount of drug used, the situation in which it is used, the personality, experience and expections of the user and the prevailing attitudes of society towards the use of that drug. Although the benzodiazepines are structurally related, they do not participate in the same routes of biotransformation. Therefore the drug prescribed may depend upon the patient's diet or other...

Enhancing performance the American way

The use of artificial means to improve performance has long been considered wholly incompatible with the spirit of sport and has therefore been condemned. Nevertheless, we all know that this rule is continually being broken, and that sportive competitions are often more a matter of doping than of training. It is highly regrettable that those who are in charge of supervising sport seem to lack the energy for the campaign against this evil, and that a lax, and fateful, attitude is spreading. Nor are the physicians without blame for this state of affairs, in part on account of their ignorance, and in part because they are prescribing strong drugs for the purpose of doping which are not available to athletes without prescriptions.

Disturbances of psychomotor function

Anxiety and depression have been reported after the use of nadolol, which is hydrophilic (163). In a study of the co-prescribing of antidepressants in 3218 new users of beta-blockers (164), 6.4 had prescriptions for antidepressant drugs within 34 days, compared with 2.8 in a control population. Propranolol had the highest rate of co-prescribing (9.5 ), followed by other lipophilic beta-blockers (3.9 ) and hydrophilic beta-blockers (2.5 ). In propranolol users, the risk of antidepressant use was 4.8 times greater than the control group, and was highest in those aged 20-39 (RR 17 95 CI 14, 22).

Contraception misconception

It is estimated that the average woman would have 12-15 children in her lifetime without the use of contraception. But there have been dramatic increases in the number of pharmacists that are refusing to dispense birth control or emergency contraception to patients who have a legitimate prescription in dozens of states. Often, these pharmacists are located in towns where they are the only means for people to get prescription drugs. With no alternative means of acquiring contraception, women in these towns are being subjected to the moral objections of their pharmacist despite the fact that they are trying to acquire an FDA-approved, doctor-prescribed medication. These pharmacists are not just located in mom and pop pharmacies either they are in national chains like CVS and Walgreens. The individual cases are disturbing from women being refused emergency contraception after being raped to refusing mothers with multiple children the pill to prevent them from having more children or who...

Schedules of Controlled Substances

Schedule II These drugs have a currently accepted medicinal use and have a high potential for abuse and dependence. A written prescription is required by a physician who is registered with the Drug Enforcement Administration (DEA). Telephoned prescriptions refills are not allowed. Examples opium derivatives (e.g., morphine, codeine), meperidine (Demerol), methadone, Fentanyl, cocaine, amphetamines (Dexedrine) and short-acting barbiturates (e.g., Nembutal, Seconal). Schedule III Medicinal drugs with potential for abuse and dependence liability less than Schedule II, but greater than Schedule IV. A telephoned prescription is permitted to be converted to written form by the dispensing pharmacist. Prescriptions must be renewed every six months and refills are limited to five. Examples paregoric, some appetite suppressants (e.g., Didrex, Tenuate), some hypnotics (e.g., glutethimide, methyprylon) and dronabinol (Marinol) a synthetic THC. Schedule V Medicinal drugs with the lowest potential...

Alcoholization French alcoolsation

Alepam Oxazepam. Alepsal Phenobarbital. Alepsia Phenobarbital. Alepsina Phenobarbital sodium. Alerbuf Phenobarbital. Alergin Phenobarbital. Alergowas asma Barbital. Alerta Colloquial term for vigilant, alert. Alertol Pipradrol hydrochloride. Alertonic Pipradrol hydrochloride. Alertyl Amfetamine sulfate. Alexander the Great 356-323 B.C. King of Macedonia (336-323) and conquerer of Asia Minor, Syria, Egypt, Babylonia, and Persia. His reign marked the beginning of the Hellenistic Age. Described by many historians as an alcoholic. The theory has been advanced that he was actually an alcoholic having, for example, killed his friend Clitus in a drunken fury. He later regretted this act deeply. Alexithymia No words or feelings.Elusive or absent feelings due to continuos drug misuse. The term was introduced 1972 by P.E. Sife-

Adulteration and Contamination

Adulteration in Asian medicines mostly results from the misidentification of plants. This has resulted in a number of serious events, primarily due to poisoning with digitalis, belladonna, skullcap, etc. 8 . In 1998, the California Department of Health reported that 32 of Asian patent medicines sold in the US contained undeclared pharmaceuticals or heavy metals 60, 61 . The FDA and other investigators have also reported the presence of prescription drugs, including glyburide, sildenafil, colchicines, adrenal steroids, alprazolam, etc. in products claiming to contain only natural ingredients 62 .

OTC Classification After OTC Drug

Phrey amendment that if a drug can be OTC, it should be OTC (23, 30). Prescription status should be an exception. However, the history of drug approval suggests otherwise. Most new chemical entities are initially approved as prescription drugs, which may then be switched after a period of at least 5 years cf marketing experience and meeting certain switch criteria (29). Direct OTC approval of new chemical entity is a rare phenomenon. 3.1.4 Criteria for Reclassification of Drug Rx-to-OTC Switch. The terms reclassification and Rx-to-OTC switch can be used interchangeably (25, 27, 30-37). There are many drivers for Rx-to-OTC switch. Pharmaceutical companies use Rx-to-OTC switch to increase the lifespan and profitability of a prescription drug that is coming off patent. Switch can also expand the market by tapping into a new patient population that previously can not be reached as a prescription product. An example is Imodium (38). Healthcare providers and governments who fund national...

Teenage Trends and Attitudes

Hallinogen Trand Image

The National Household Survey on Drug Abuse (NHSDA) is directed by the Substance Abuse and Mental Health Services Administration. Since 1971, the NHSDA has provided annual estimates of the prevalence (patterns of use) of illicit drug, alcohol, and tobacco use in the United States and has monitored trends since that time. Results from this survey are based on representative samples of the United States population aged 12 and older. The illicit drug category includes marijuana, cocaine, heroin, hallucinogens, inhalants, and the nonmedical use of prescription drugs. Hallucinogens as a group include LSD, peyote, mescaline, mushrooms (psilocybin), and PCP, but only LSD and PCP are broken out of this subcategory in For almost 30 years, the Drug Abuse Warning Network (DAWN) has been an ongoing national data system that collects information on drug-related visits to a sample of U.S. hospital emergency departments (ED). The ED visit has to be directly related to the use of an illegal drug or...

Alcohol and Drug Interactions

Alcohol increases sedative effect of tricyclic antidepressants (TCAs) through pharmacodynamic interactions. In addition, alcohol can also cause pharmacokinetic interactions. Alcohol appears to interfere with first-pass metabolism of amitriptyline, thus increasing serum levels of this drug. Alcohol has pharmacodynamic effects with antihistamines, increasing the sedative effects of these over the counter and prescription drugs. Alcohol also increases the sedative effect of phenobarbital and may also increase its serum concentration through pharmacokinetic interactions. Interactions between benzodiazepines and alcohol have also been reported. Alcohol consumption may result in accumulation of toxic breakdown products of acetaminophen (59).

Babasol No 2 1 Barbital 2 Barbital sodium

Backbuck Colloquial term for neck of a bottle used for smoking hashish. Backdoor artist Colloquial term for drug misuser who specializes in cheating other drug misusers. A dangerous complication after bacterial attacks are blood poisoning, sepsis. Bacteria in the circulation of the blood can also attack the cardiac valve (endocardit), the brain (brainab-cess) or the cerebral membranes (meningit). Syringe and needle exchange programs seems to reduce these risks considerably. Tuberculosis, caused by the tubercle bacillus has since the beginning of the 1990s had a rapid spread especially among HIV-positive drug misusers in the bigger cities in USA and Europe, in some cases it is multi-resistent tubercle bacillus. Bad scrip passer Colloquial term for person who steals and forges prescriptions. Bad script Colloquial term for forged prescription.

What Drug Give Negative And Positive Result With Trinder Test

Immunoassays have been developed to screen for the presence of other illegal drugs, including cannabinoids, LSD, and prescription drugs such as propoxyphene, methadone, and methaqualone. With the exception of cannabinoids and LSD, all of the analytes are readily detected by either ToxiLab A or GC basic drug screens. Cannabinoid and LSD assays may be included in a standard screening

Psychedelics And Society

For virtually every drug there is a portion of the population which will have an undesirable response. Medical journals are replete with descriptions of drug damage and fatalities. In the US, penicillin and aspirin each account for some 200 deaths yearly, and it was recently estimated that prescription drugs are implicated in the deaths of some 29,000 Americans a year. The most toxic drug commonly ingested in large amounts is probably nicotine about three cigarettes contain a lethal dose (although some brands now require two packs or more for a lethal dose). In contrast, the psychedelics seem to be relatively safe and non-toxic. Some people, perhaps one in a hundred, can develop a temporary psychosis which rarely lasts more than a few hours or days, and which generally seems to indicate preexisting psychopathology. In a more enlightened future, psychedelics may be universally applied to expose latent mental illness. There is no sound evidence that any psychedelic damages human brains,...

Respiratory effects of inhaled cannabis vapor andor smoke

Cannabis Respiratory Effect

PAIN Pain control is possible not only by consuming cannabis flowers, but possibly even the leaves, because, along with THC, cannabidiol (CBD) seems to have a major analgesic (pain lowering) effect. Not all pain responds to cannabinoids, but some of the most troublesome ones do. Neuropathy and neuralgia both respond well, while acute injury pain gets less immediate relief but eventually feels diminished. Cannabis has synergistic effects with opiates and other drugs, so pain patients can reduce their dosages of prescription drugs that have adverse side effects.

What Counts as a Drug and Where Does a Drug Count A Policy View

These prescription drugs is one of the largest, most profitable, and important segments of the U.S. and global market. Yet at the same time, children are taught that drugs are bad through programs such as Drug Abuse Resistance Education (DARE) and nationwide public-relations campaigns aimed at reductions in substance abuse they are taught to just say no to drugs. Recognizing these differences in perceived meanings of the term drug, clinicians today are often advised to use the words medicine or medication rather than drug when describing therapeutic substances, under the assumption that the negative connotations of the term drug can decrease patient adherence to prescribed medication regimens. Drug manufacturers speak of themselves as the pharmaceutical industry, perhaps to distance themselves from another highly lucrative drug industry, the illegal one, that also flourishes in the United States and around the world. Whether a therapeutic agent is medicinal is often controversial and...

Oral Hypoglycemic Drugs

A retrospective analysis of a pharmacy database of over 60 million Americans has shown that many do not persist in taking particular oral hypoglycemic drugs (51C). Of 11.6 million patients identified as continuously benefit-eligible for mail and retail prescriptions, 136 466 had received a first prescription for an oral hypo-glycemic drug between 1 October 1997 and 31 March 1999. The 12-month persistence rate ranged from 31 for a-glucosidase inhibitors to 60 for metformin. Compliance rates were 70-80 , and 36 of the patients who continued to use oral drugs changed treatment one or more times. The number of changes increased with increased follow-up, and more than half of the patients had at least one change in therapy.

Future Trends For Otc And Lifestyle Drugs

Pharmaceutical companies and government used to the two major drivers for Rx-to-OTC switches and they will continue to be the maior drivers for the switches. The former conducts switches for lifestyle management of prescription drugs while the latter promotes switches to reduce national prescription costs. In future, manage care providers will also be a major driver to petition for switches as in the case of second-generation antihistamines. diseases and disorder and genomic research, pharmaceutical scientists can now create drugs to target receptors that were previously unknown. To maintain double-digit growth, the pharmaceutical industry cannot just focus on unmet consumer needs in the area of life-threatening conditions such as cancer, asthma, anti-infective diseases, and cardiovascular diseases. They also need to capitalize on unmet consumer needs in the area of lifestyle enhancement to the aging consumers. The growth in the market for lifestyle drugs will likely be faster than...

Fluoxetine Sertraline Paroxetine Citalopram Fluvoxamine

Drug Sertraline Mechanism Action

Oddly, there is a mystique about Prozac, even as it becomes more and more commonplace in people's lives. More and more prescriptions are filled every year, often by family doctors with little knowledge of psychology, and the prescriptions are often for behaviors not related to mood, such as kleptomania, weight gain, or neuropathic pain. Is Prozac truly a panacea for such a wide scope of problems and populations Or is the hype of Prozac over-reaching its powers This chapter will attempt to pull the curtain away from Prozac mythology with a discussion of SSRI benefits and drawbacks.

From high school to pro sports in America

Accused of supplying 1,750 pills (5 mg to 15 mg each) over a three-month period, including 400 pills each to two players, he decided to speak out and reveal the extent of drug use in football. In 1976 he published a book called The Nightmare Season and ended up being reprimanded by the California Board of Medical Quality Assurance for writing excessive prescriptions. Mandell was a highly qualified scientist, a recognised expert on neurochemistry and author of numerous papers and books, as well as the founding chairman of the Department of Psychiatry at San Diego (Donohoe and Johnson 1986). Such was the widespread expectation that drugs would be available that team doctors became embroiled in doping and ran into personal and career problems.

Educating the Client on the Use of Herbs and Nutritional Supplements

The use of herbs and nutritional supplements to treat various disorders is common. Herbs are used for various effects, such as to boost the immune system, treat depression, and for relaxation. Individuals are becoming more aware of the benefits of herbal therapies and nutritional supplements. Advertisements, books, magazines, and Internet sites abound concerning these topics. People, eager to cure or control various disorders, take herbs, teas, megadoses of vitamins, and various other natural products. Although much information is available on nutritional supplements and herbal therapy, obtaining the correct information sometimes is difficult. Medicinal herbs and nutritional substances are available at supermarkets, pharmacies, health food stores, specialty herb stores, and through the Internet. The potential for misinformation abounds. Because these substances are natural products, many individuals may incorrectly assume that they are without adverse effects. When any herbal remedy...

Most Parents Dont Know If Their Teen Is Depressed

Obesidad Sobrepeso Quotes

The use of new antipsychotic medications, such as Risperdal, has grown nearly 300 percent. The only prescription drugs not exhibiting huge rises in use are stimulants (typically for treatment of ADHD). For children under 18 years old, the number of prescriptions written for Ritalin-like drugs is up 23 percent. This smaller increase is mostly due to the fact that attention-deficit hyperactivity disorder is not as stigmatized as teenage depression. During the past ten years, it was much easier to get treated for ADHD than depression. This study illustrates that treatment of mood disorders was much more prevalent, most likely from increasing public knowledge about the subject. For many young adults in college, there seems to be no distinct boundary separating depression from an ordinary bad mood. Numerous reports from campus medical centers describe sharp rises in depressed students and prescriptions for anti-depressants. All it takes to obtain a prescription is a quick visit to a campus...

Case 9 Self Medication for Depression Antidepressants Legal and Illegal

Depression stems either from an endogenous imbalance in a person's brain chemistry or an imbalance precipitated by the negative impact of some external event. Thus, drugs that alter brain chemistry can play a major role in depression. Some drugs cause or intensify depression, such as those that work by inhibiting various parts of the central nervous system. These include many pharmaceutical drugs used for treatment of medical conditions, and they can variously exacerbate preexisting depression, On the other hand, there are drugs, especially central nervous system stimulants, that relieve some of the symptoms of depression. These include common-use drugs like caffeine, found in coffee, tea, colas, energy drinks, and various stay-awake nonprescription OTC medications like NoDoz (see case 4). The dietary supplement St. John's wort is a mild antidepressant, although it can cause clinically important drug interactions (see case 7), and other dietary supplement stimulants, such as ephedra,...

Traditional Chinese Medicine

Traditional Chinese medicine (TCM) has been in practice for more than 200 years and includes acupuncture, massage (tuina), breathing exercise (qi gong) and dietary therapy. TCM has been an integral part of China's healthcare system along with conventional Western medicine. TCM products were safe and effective for the treatment of many human diseases before Western medicine was introduced in China. Famous texts in TCM include the Yellow Emperor's Inner Classic (Hung Di Nei Jing 200 BCE to 100 CE), Divine Husband-man's Classic of Materia Medica (Shen Nong Ben Cao Jing 25-220 AD) and cold-induced disorders (Shang han Lun 220 AD). The most complete reference to Chinese herbal prescriptions is Chinese Materia Medica, published in 1977. It lists nearly 6000 drugs, of which 480 are of plant origin. This ancient system of medicine, believed to be more than 5000 years old, is based on two separate theories about the natural laws that govern good health and longevity, namely 'Yin and Yang',...

Are prescribed at the same time

An extreme adverse effect of drug treatment is an attempt by a patient to kill himself by overdosing on a psychotherapeutic drug. Whatever the motivation, doctors should be aware of this risk and prescribe the safest possible drugs. It is good practice to write non-refillable prescriptions for small quantities of drugs when suicide is a possibility. In extreme cases, attempts should be made to verify that patients are actually taking the medication and not hoarding the pills for a later overdose attempt It is a common clinical observation that patients may attempt suicide just as they are beginning to get better. Clinicians, therefore, should continue to be careful about prescribing large quantities of medication until the patient is almost completely recovered. Another consideration for psychiatrists is the possibility of accidental overdose, particularly by children in the household.

Toxicity of Herbal Drugs

Two kinds of side effects have been reported for herbal medicines. The first, considered to be intrinsic to herbal drugs themselves, is mainly related to predictable toxicity due to toxic constituents of the herbal ingredients and overdosage, and the second is allergy. Many cases of allergic reactions have been reported for herbal drugs. It is impossible to completely eliminate the possibility of any substance, including prescription drugs, herbal remedies, or cosmetics, producing an allergic response in people exposed to them. Herbal medicines do not present any more of a problem in this respect than any other class of widely used foods or drugs. Perhaps the major problem with regard to the safety of herbal medicines is related to the manufacturing practice, including contamination, substitution, incorrect preparation and dosage, intentional addition of unnatural toxic substances, interactions involving synthetic prescriptions, drugs, and herbal medicines, either intentional or...

Case 1 Opioid Drugs for PainIs the Solution Worse Than the Problem

Poor pain management by clinicians often results from inconsistent laws, definitions, and regulations pertaining to medication control. To be sure, effective pain management frequently requires a multimodal and interdisciplinary approach. However, medications remain the cornerstone of care for the majority of patients, whether in the form of over-the-counter drugs like NSAIDS or prescription drugs like opioids, with the latter continuing to be the most effective analgesics for most moderate to severe pain. But because opioids are associated with potential toxicities and concerns about abuse and addiction, a maze of real and perceived laws, regulations, and precautions pertaining to their use has evolved, and many clinicians hesitate to use opioids consistently, even when they are medically indicated. Indeed, many doctors are reluctant to use opioid drugs at all even when the patient would clearly benefit.

Treatment should have the shortest possible duration

More often than not, non-pharmacological means, such as counselling, will be both applicable and effective, and without risk of drug misuse or drug dependence. The decision to treat with drugs should be based on a clinical determination that the patient's psychological and social resources have been, or are in danger of being, overwhelmed for example, a sustained period of inability to sleep following the death of a loved one represents a typical case in which pharmacological treatment of insomnia may be considered. The clinical question is, can this patient, within the limits of the available resources, regain equilibrium without drug therapy If the answer is yes, and particularly if the answer is yes with relatively bearable suffering or

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