Vitamin B6 pyridoxine

Pharmacology and toxicology

Pyridoxine is the co-enzyme of some amino acid decarboxylases and transaminases. Vitamin B6 is used in North America in combination with doxyiamine as therapy for excessive vomiting in pregnancy (hyperemesis) (see Chapter 2.4). The vitamin B6 concentration in the mother's blood is reduced throughout the entire pregnancy. By contrast, the concentrations in the fetal blood are about three times as high (Cleary 1975). There is no indication as yet for teratogenicity (see Chapter 2.4).

Recommendation. Supplementation with vitamin B6 is only necessary in exceptional cases, for example during tuberculostatic treatment with isoni-azid (see Chapter 2.6). For treatment of nausea and vomiting in pregnancy, see Chapter 2.4.

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