Pharmacology and toxicology
Riboflavin is an important co-enzyme in energy metabolism. In newborns whose mothers had clinical or laboratory signs of riboflavin deficiency, no developmental disorders could be shown (Heller 1974). The same study showed that the vitamin B2 concentration in the cord blood was four times as high as in the maternal blood. It would appear that an active transplacental transport of vitamin B2 prevents deficiency in the fetus. A suggestion has been made that riboflavin hypovitaminosis might be an additional risk factor for pre-eclampsia (Wacker 2000).
Recommendation. Supplementation with vitamin 82 during pregnancy is, as a rule, unnecessary. Embryo- or fetotoxicity with an overdose of riboflavin has not been reported.
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