Pharmacology and toxicology
A new approach in asthma therapy is the use of monoclonal antibodies against IgE. Omalizumab was introduced in 2005. There is no experience with its use in pregnancy yet.
The so-called PDEH-typc-4 agent roflumilast has not yet been licensed. It has anti-inflammatory but no bronchodilating properties, is orally available, and may be effective in chronic obstructive lung diseases. There is no experience in pregnancy with roflumilast or with cilomilast.
Recommendation. The use of these new agents should be avoided in pregnancy. In the case of first-trimester exposure, a detailed fetal scan should be offered. It is not an indication for the termination of pregnancy.
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