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Pharmacology and teratology

Methinamine salve is a topical therapeutic used in cases of excessive sweating. There have been no systematic studies regarding the safety of this substance during pregnancy. The resorption from local application is low. There is no documented experience with intracutaneous application of C. botulinum toxin (botox) preparations. However, the risk for systemic toxicity is remote (see also section 2.22.8).

Recommendation. Methinamide can be used in pregnancy when it is applied on a small skin area. C. botulinum toxin must not be used in pregnancy. However, inadvertent exposure does not justify either interruption of pregnancy or invasive diagnostic procedures.

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