Mescaline Lsd And Psilocybin Birds Of A Feather

Three of the most common hallucinogenic drugs used today are mescaline, LSD, and psilocybin. Some people insist that these three drugs produce the same psychological effects, and even some experienced users cannot tell the effects of each drug apart. Others, however, believe that the effects produced by psilocybin, LSD, or mescaline are unique. Several key pharmacological differences between these drugs are outlined in the table below:

MESCALINE

LSD

PSILOCYBIN

Average dose

200-500 mg

0.05-0.2 mg

20-40 mg

Potency (relative

2000x

20x

to mescaline)

stronger

stronger

Time to onset

1-3

30-40

20-30

of effects

hours

minutes

minutes

Duration

12+

8-12

4 hours

of effects

hours

hours

Occurrence

Rare

Common

Rare

of flashbacks

the cerebral cortex. This region, which constitutes the bulk of our brain mass, is the highly wrinkled, outermost part of our brain (see Figure 1.4 in chapter 1), where thinking and planning are regulated. The cerebral cortex also processes sensory information coming from our eyes, ears, nose, mouth, and skin. As it turns out, the cerebral cortex is packed full of 5-HT2 receptors, which are located on many neurons in this region. Scientists have found that stimulation of 5-HT2 receptors in the cerebral cortex by mescaline causes these neurons to release their primary neurotransmitter, glutamate. In addition, the

Difference Between Lsd And Mushrooms

Psilocybin

Psilocybin

6 Infobase Publishing

Figure 4.3 Chemical structure of LSD and psilocybin changes in the activity of neurons in the LC, which release norepinephrine onto neurons in the cerebral cortex, also produce the release of glutamate in this region. This release of

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