Subcellular Location

5-HT receptors, like all types of receptors can be found at two main subcellular locations which are somatodendritic and preterminal positions. The somatodendritic receptors modulate the firing rate of the neuron (indirectly controlling the neurotransmitter release in termi-

Figure 3. Sites of action of 5-HT receptor subtypes in different neuronal compartments (soma, dendrites, axon terminals) in the septo-hippocampal and basal forebrain-cortical complexes. Schematic representation of data obtained by different authors by using electrophysiology, microscopy and neurotransmitter release methods (see text for references). The functional consequences of the activation of 5-HT receptors are indicated (when known) by an upward arrrow ( f ) for an excitatory effect, and a downward ( j ) arrow for an inhibitory effect on the target cell (with ? signifying uncertainties). For definitions, please refer to the list of abbreviations.

Figure 3. Sites of action of 5-HT receptor subtypes in different neuronal compartments (soma, dendrites, axon terminals) in the septo-hippocampal and basal forebrain-cortical complexes. Schematic representation of data obtained by different authors by using electrophysiology, microscopy and neurotransmitter release methods (see text for references). The functional consequences of the activation of 5-HT receptors are indicated (when known) by an upward arrrow ( f ) for an excitatory effect, and a downward ( j ) arrow for an inhibitory effect on the target cell (with ? signifying uncertainties). For definitions, please refer to the list of abbreviations.

nals), while preterminal receptors directly control the release of neurotransmitter. Thus, 5-HT receptors can be grouped into three main categories: 1) somatodendritic (5-HT1A, 5-HT3, 5-HT6), 2) preterminal (5-HT1B), 3) both somatodendritic and preterminal (5-HT2, 5-HT4). In addition, receptors can be either auto- or heteroreceptors: Autoreceptors are located on serotonergic neurons whereas heteroreceptors are found on non5-HT-releasing neurons. Autoreceptors have been found in the raphe (5-HT1A, 5-HT1D) and in different projecting areas, such as the septum, hippocampus, the NBM or the entorhinal and frontal cortices (5-HT1B). Heteroreceptors are present in all anatomical structures mentioned above.

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