Cannabinoids Pharmacokinetics and Drug Analysis

Metabolic Transformations

Cannabinoids immunoassays for each type of biological matrix have to be designed and interpreted in the context of A9-THC absorption and metabolism. The Fig. 1. Chemical structure of naturally occurring cannabinoids. 21 CFR 862.3870 defines a cannabinoid test system as a device intended to measure any of the cannabinoids, hallucinogenic compounds endogenous to marihuana, in serum, plasma, saliva, and urine. Cannabinoid compounds include A9-tetrahydrocannabinol, cannabidiol, cannabinol, and...

Basal Ganglia and Cerebellum

Basal Ganglia Cerebellar Pathways

The basal ganglia and the cerebellum interact with the cortex through a series of feedback circuits. The basal ganglia, a group of midbrain nuclei, are involved mainly with the initiation and execution of a movement, whereas the cerebellum tends to modulate ongoing movement (Fig. 5). Again, pathology clearly describes the role played by these structures in motor coordination. The most relevant disorders are the dyskinesias, or abnormal movements. Basal ganglia degeneration results in movement...

Resin Gland Anatomy and Development

Gland Heads Cannabis

As resin gland development commences, the medically important cannabinoids and the associated terpenes begin to appear. Although the cannabinoids are odorless, terpenes are the primary aromatic principles found in the essential oil of Cannabis (9,10). Most interesting economically and medically are the cannabinoid-rich terpenoid secretions of the head cells of glandular hairs densely distributed across the myriad surfaces of the female flowers. Male plants are of no consequence in medicine...

Chemistry and Classification

So far, 66 cannabinoids have been identified. They are divided into 10 subclasses 8-10 see Table 1 . From Forensic Science and Medicine Marijuana and the Cannabinoids Edited by M. A. ElSohly Humana Press Inc., Totowa, New Jersey Main pharmacological characteristics 1. Cannabigerol CBG type CBG was the first cannabinoid identified 11 , and its precursor cannabigerolic acid CBGA was shown to be the first biogenic cannabinoid formed in the plant 12 . Propyl side-chain analogs and a monomethyl...