The Building Blocks

The visions, ecstatic states, and flights of imagination made possible by psychedelic drugs gave these substances an important role in many ancient cultures. Hundreds ofyears of anthropological research have demonstrated that these societies used psychedelics to maintain social solidarity, aid the healing arts, and inspire artistic and spiritual creativity. New World aboriginal people used, and continue to use, a wide range of mind-altering plants and mushrooms. Most of what we know about...

What DMT Is

IN , N-dimethyltryptamine, or DMT, is the remarkable main character of this book. While chemically simple, this spirit molecule provides our consciousness access to the most amazing and unexpected visions, thoughts, and feelings. It throws open the door to worlds beyond our imagination. DMT exists in all of our bodies and occurs throughout the plant and animal kingdoms. It is a part of the normal makeup of humans and other mammals marine animals grasses and peas toads and frogs mushrooms and...

The Spirit Molecule

It is almost inconceivable that a chemical as simple as DMT could provide access to such an amazingly varied array of experiences, from the least dramatic to the most unimaginably earth-shattering. From psychological insights to encounters with aliens. Abject terror or nearly unbearable bliss. Near-death and rebirth. Enlightenment. All of these from a naturally occurring chemical cousin of serotonin, a widespread and essential brain neurotransmitter. It is just as fascinating to ponder why...

The Pineal Meet the Spirit Gland

V_Jne of my deepest motivations behind the DMT research was the search for a biological basis of spiritual experience. Much of what I had learned over the years made me wonder if the pineal gland produced DMT during mystical states and other naturally occurring, psychedelic-like experiences. These are ideas I developed before performing the New Mexico research. In chapter 21, I enlarge these hypotheses to incorporate what we discovered during the experiments themselves. In this chapter I will...

Contact Through the Veil

1 he material in this and the next chapter is the most unusual and difficult to understand. It is the weirdest and the easiest for me to skirt when people ask What did you find When reviewing my bedside notes, I continually feel surprise in seeing how many of our volunteers made contact with them, or other beings. At least half did so in one form or another. Research subjects used expressions like entities, beings, aliens, guides, and helpers to describe them. The life-forms looked like clowns,...

Info

_Cjven before I began the melatonin study, my review of the literature indicated it might not be the spirit molecule. I wondered if the pineal gland made other compounds with psychedelic properties. However, while still in the early stages of my career, and well before I began outlining my DMT project, I quickly discovered how controversial these ideas could be. In 1982 I undertook a year of clinical psychopharmacology research training at the University of California in San Diego. While I...

Getting DMT

1 welve subjects participated in the original dose-response study, which took most of 1991 to perform. They each received non-blind low and high doses of DMT and subsequently got the same doses double-blind. Two intermediate doses and a saline placebo completed this series of injections. Once we had thoroughly characterized DMT's effects in the dose-response study, the first follow-up project investigated whether it was possible to develop tolerance to repeated injections of DMT. Tolerance...

Acknowledgments

VAountless colleagues, committees, and agencies helped with all stages of this research. Several deserve special mention. The late Daniel X. Freed-man, M.D., from UCLA's Department of Psychiatry, advocated for these projects at all levels and was instrumental in my obtaining crucial early funding. Staff at the U.S. Food and Drug Administration and the U.S. Drug Enforcement Administration were extraordinarily flexible and responsive to the unusual circumstances of this research. Clifford Quails,...