Uttam Garg PhD

Contents

1. Introduction

2. Hair

3. Oral Fluid

4. Sweat

5. Meconium

6. Other Matrices and Other Drugs

7. Conclusions

Urine is the most widely used specimen for the detection of and analysis of abused drugs. However, commonly abused drugs can only be detected 1-3 days after abuse using urine specimens. Urine collection, for forensic purposes, requires a special collection facility. Despite strict rules for specimen collection, due to privacy issues in urine collection, sample adulteration is not uncommon. The other matrices provide solutions to some of these problems and have additional advantages for drug testing programs. Hair analysis provides non-invasive and supervised sample collection with the largest window of drug detection period (>90 days). Oral fluid analysis provides a convenient way of sample collection under direct supervision and is useful in assessing very recent drug use. The sweat drug analysis provides continuous monitoring of drug use for several weeks. Meconium is a good specimen for detection of intrauterine drug exposure. Despite many advantages, these matrices pose special challenges, particularly analytical and interpretation of results.

Key Words: Hair; oral fluid; sweat; meconium; drugs of abuse.

Summary

From: Handbook of Drug Monitoring Methods Edited by: A. Dasgupta © Humana Press Inc., Totowa, NJ

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