Therapeutic Antibodies

These are antibodies used in therapy. One example is Digibind™ (Glaxo/Burroughs Wellcome), the Fab fragments from ovine anti-digoxin antibodies which is a specific antidote for life threatening digoxin overdose. Digibind interferes with most digoxin immunoassays that do not require sample pretreatment. This type of interference in digoxin immunoassay is discussed in Chapter 6. However, interference from Digibind in serum digoxin measurement can be eliminated by ultrafiltration and measuring digoxin in protein-free ultrafiltrate (4).

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