Substances Known to Metabolize to Methamphetamine and Amphetamine

Many medications and substances are known to metabolize to methamphetamine or amphetamine, thus giving analytical true positives (Table 2). If a patient is on one of these medications, the positive result is a clinical false positive. Enantiomeric analysis may be useful in verifying that the positive result was due to the use of a prescription drug. For example, selegiline, a drug used in the treatment of Parkinson's

Table 2

Examples of Amphetamines-Containing products3

Amphetamines-containing Products

Substances known to contain d-amphetamine or d,/-amphetamine

Substances known to contain d-methamphetamine

Substances known to contain /-methamphetamine

Substances known to metabolize to methamphetamine (and amphetamine)

Substances known to metabolize to amphetamine

Adderall®

Dexedrine®

DextroStat®

Desoxyn®

Vicks Inhaler®

Benzphetamine (Didrex®)

Dimethylamphetamine

Famprofazone

Fencamine

Furfenorex

Selegiline (Eldepryl®)

Amphetaminil

Clobenzorex

Ethylamphetamine

Fenethylline

Fenproporex

Mefenorex a Medical Review Officer Manual for Federal Agency Workplace Drug Testing Programs http:// dwp.samhsa.gov/DrugTesting/Level_1_Pages/HHS%20MRO%20Manual%20 (Effective%20November% 201,%202004).aspx (accessed 11/05/2006).

disease, is metabolized to /-methamphetamine (and /-amphetamine) without any racem-ization during metabolism (7). Given the immunospecificity of most amphetamines immunoassay is mostly directed toward d-methamphetamine, and given the fact that /-methamphetamine and /-amphetamine concentrations derived from selegiline metabolism are relatively low, urine specimens of patients on selegiline most likely would not test positive. Should there be a positive initial test, enantiomeric analysis should show the presence of only the /-isomer if the patient has taken selegiline (5). Clobenzorex is metabolized to d-amphetamine. Therefore, enantiomeric analysis should show only d-amphetamine; the presence of the /-amphetamine is inconsistent with the sole use of clobenzorex (8).

Drug Addiction Report

Drug Addiction Report

You're going to discover so many things on addiction with little effort Not only will you discover the thrill of breaking free from your addiction, but you'll also learn extra bonus tips to actually help other people This new breakthrough book is a guide, really. A guide as a result of years of searching, studying, and scouring hundreds of websites, stores, and magazines.

Get My Free Ebook


Post a comment