Phencyclidine

PCP has been detected in oral fluid, and good correlation has been found between oral fluid and serum concentrations. In one study using 100 patients from an emergency department suspected of using PCP, 74 oral fluid specimens and 75 serum specimens were found positive for PCP. The method used was RIA and there was no correlation between PCP concentrations and severity of intoxication (78). Though there is a good correlation between oral fluid and plasma PCP concentrations, intra- and interindividual variability are high, and ratio of oral fluid to plasma concentration varies with pH. Therefore, oral fluid PCP concentrations cannot accurately predict plasma concentrations. The frequently used methods for analysis of PCP in oral fluid include immunoassays, GC-MS and LC-MS.

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