Oh

Valproic Acid

Valproic Acid

Fig. 5. Oxcarbazepine.

Phénobarbital

Fig. 6. Hydroxyzine.

generation antihistamine with sedative properties. Hydroxyzine is also one of the drugs used in the firstline therapy for the treatment of allergic rhinitis and chronic idiopathic urticaria (37,38). Hydroxyzine is structurally unrelated to carbamazepine, but in that report, Parant et al. documented two cases where hydroxyzine in serum caused false-positive carbamazepine levels using the PETINIA (Dade Behring) assay. A 22-year-old female with a hydroxyzine concentration of 1.77 ^g/mL and cetirizine concentration of 2.1 ^g/mL showed an apparent carbamazepine level of 5.3 ^g/mL. Another patient with a hydroxyzine level of 520ng/mL and cetirizine level of 2.18 ^g/mL demonstrated a carbamazepine level of 25.4^g/mL . The authors of this study also demonstrated cross-reactivity of the PETINIA assay with cetirizine, oxatomide, and other benzhydrylpiperazine drugs. However, EMIT 2000 assay for carbamazepine showed no cross-reactivity (36).

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