Lysergic Acid Diethylamide

Lysergic acid diethylamide (LSD), a very potent hallucinogen taken in very small doses (typically <1 mg), is extensively metabolized. As a result, urinary concentration of LSD is very low, usually in the sub-nanogram per ml range. The cutoffs used in LSD immunoassays (EMIT, CEDIA, KIMS, ELISA, and RIA) are usually 0.5 ng/ml. The window of detection is 24 h or less (33). The homogenous immunoassays, the enzyme immunoassay in particular (EMIT), are known to have poor immunospecificities, and false-positive results have been reported as a result of the interferences of tricyclic antidepressant and antipsychotic medications (34,35). LSD is light sensitive and urine specimen should be protected from light during storage of specimen prior to analysis.

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