Issues of Speciallnterest in Sweat Testing

1. In one study, the effect of 18 adulterants on EIA and GC-MS for opiates was investigated (83). The patches were spiked with adulterants and air-dried, then spiked with 15ng/mL heroin, codeine or morphine and incubated at 37°C for 7 days. Most of the adulterants tested did not have any effect with the exception of a few (Table 8). Moreover, exposure of the skin to many of these adulterants causes visible inflammation and discomfort to the subject, decreasing the possibility of their use.

2. The average pH of sweat is 5.8. During exercise, the pH increases to an average of 6.4. The change in pH may affect the migration of drugs in sweat.

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