Is dlis a natriuretic hormone

Serum DLIS concentrations are elevated in volume-expanded patients. DLIS can also inhibit Na, K-ATPase. In addition, it has been associated with natriuresis, thus raising the possibility that DLIS play a role in water and sodium homeostasis. Garbagnati demonstrated that children with elevated concentrations of DLIS showed significantly lower natremia, higher urinary and fractional excretion of sodium, and increased systolic blood pressure compared with children with no measurable DLIS concentration (34). Ebara et al. (51) prepared DLIS from cord blood of healthy full-term infants by acetone/hydrochloric acid extraction followed by purification with a gelfiltration column and demonstrated natriuretic activity of DLIS in a rat model. Goodline reported a case where the blood pressure of a pregnant woman with preeclampsia was reduced significantly after intravenous treatment with the Fab fragment of anti-digoxin antibody. This was probably because of binding of free DLIS with Fab (52). However, there are other reports in the literature that dispute the link between elevated DLIS and natriuresis. Scott et al. (53) did not find any difference in circulating levels of DLIS in normotensive and hypertensive rabbits despite marked alteration in dietary sodium intake. Trachtman et al. (54) concluded that a rise in DLIS concentration does not lead to an increase in blood pressure.

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