Drugherb Interactions

Mechanism of drug-herb interactions can be classified under several categories:

1. Herbal product may increase the clearance of a Western drug leading to unexpected lower concentration of a therapeutic drug. St. John's wort, a herbal anti-depressant, increased clearance of many Western drugs.

2. An herbal remedy may have a synergistic effect of increasing pharmacological activity of a Western drug or may decrease therapeutic efficacy of a drug.

3. An herbal remedy may displace a Western drug from serum protein increasing free drug concentration, the pharmacologically active component of a drug. Common drug-herb interaction are summarized in Table 2.

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