Criteria for DLIS

DLIS can be divided into two groups. One class of DLIS interferes only with digoxin immunoassays because of their cross-reactivity with anti-digoxin antibody, and the other class of compounds inhibits or binds with Na, K-ATPase. These compounds may also cross-react with anti-digoxin antibody. Because of the ability of DLIS to inhibit Na, K-ATPase, it was hypothesized that DLIS is a natriuretic hormone. Several studies have been reported where investigators took advantage of digoxin-like immunoreactivity and Na, K-ATPase-binding ability of DLIS to purify these compounds from intact cells or isolated receptors. These investigators also studied the biochemical and or physiochemical parameters of isolated DLIS (16-18).

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