Conclusions

As shown by the literature reviewed, the pre-analytical phase of TDM is extremely important. Care must be taken to assure samples are collected at the right time, under the right conditions. Although I have focused on the samples used in TDM, the lessons are applicable to those used in toxicology as well. Because of forensic needs, for example, the need to be able to replicate results with retesting at later dates, the stabilities of these analytes are probably better documented than most therapeutically monitored drugs.

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