Conclusion

The information presented has discussed the difficulties associated with the detection of specific drugs in the clinical toxicology laboratory. Several of the drugs discussed require non-routine methods for detection; therefore, having a thorough clinical history and documentation of observed effects are crucial for their subsequent detection. In addition, some of the drugs discussed have very limited detection windows or exhibit instability that may limit or prevent their detection. The end result of a "not detected" result may be due not only to the absence of analyte, but also to the specimen being collected too late for analyte detection, a lack of sensitivity of the employed analytical methodology or the degradation of the analyte during storage.

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