Catherine A Hammett Stabler PhD Dabcc Facb

Contents

1.

Introduction

2.

It Is a Matter of Time

3.

Containers: Dealing with Glass, Plastics,

Gels, and Additives

4.

Processing and Storage

5.

Avoiding Surprises: Assessing

Pre-Analytical Processes and Troubleshooting

6.

The pre-analytical phase for samples collected for the analysis of therapeutic drugs and toxins is as critical as the analytical phase. One of the most important aspects to this phase is the knowledge of the time at which the sample was collected and its relationship to the time of dosing or ingestion. These pieces of information are absolutely necessary for interpretation of the results. In addition, samples must be collected using the proper devices and processed or stored under conditions that minimize alterations to the drug concentration. In this chapter, I will review the elements that have repeatedly led to investigations and issues within the laboratory.

Key Words: Pre-analytical; blood collection tube; anticoagulants; storage.

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