Catherine A Hammett Stabler PhD Dabcc Facb





It Is a Matter of Time


Containers: Dealing with Glass, Plastics,

Gels, and Additives


Processing and Storage


Avoiding Surprises: Assessing

Pre-Analytical Processes and Troubleshooting


The pre-analytical phase for samples collected for the analysis of therapeutic drugs and toxins is as critical as the analytical phase. One of the most important aspects to this phase is the knowledge of the time at which the sample was collected and its relationship to the time of dosing or ingestion. These pieces of information are absolutely necessary for interpretation of the results. In addition, samples must be collected using the proper devices and processed or stored under conditions that minimize alterations to the drug concentration. In this chapter, I will review the elements that have repeatedly led to investigations and issues within the laboratory.

Key Words: Pre-analytical; blood collection tube; anticoagulants; storage.

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