Antiretrovirals and St Johns Wort

A patient positive for HIV and taking antiviral agents should not consume St. John's wort, Echinacea, garlic, ginkgo and milk thistle because of interactions between these herbal remedies and antiretrovirals (39). St John's wort was shown to reduce the AUC of the HIV-1 protease inhibitor indinavir by a mean of 57% and decreased the extrapolated trough by 81%. The subjects received 300mg of St. John's wort three times a day for 14 days. The mean peak concentration (Cmax) decreased from 12.3 to 8.9ng/mL in healthy volunteers taking both indinavir and St. John's wort. More significant effect was observed in C8 concentrations where the mean value was reduced from 0.494 to 0.048ng/mL in the group taking both St. John's wort and indinavir. Reduction in indinavir concentrations of these magnitudes are clinically significant and could lead to treatment failure (40). Busti et al. (41) reported that atazanavir therapy can also be affected due to simultaneous use of St. John's wort. Co-administration of lopinavir/ritonavir with St. John's wort is also not recommended because of substantial reduction in lopinavir plasma concentrations (42).

Dealing With Asthma Naturally

Dealing With Asthma Naturally

Do You Suffer From ASTHMA Chronic asthma is a paralyzing, suffocating and socially isolating condition that can cause anxiety that can trigger even more attacks. Before you know it you are caught in a vicious cycle Put an end to the dependence on inhalers, buying expensive prescription drugs and avoidance of allergenic situations and animals. Get control of your life again and Deal With Asthma Naturally

Get My Free Ebook

Post a comment