Antibodies to Other Species

After mouse, rabbit and goat are the most common animals used to generate assay antibodies for utilization in assays. Therefore, like HAMA, immunoassay interference caused by human anti-rabbit (HARA) and anti-goat antibodies have been described. While HARA interference was shown in transthyretin, haptoglobin, and C-reactive protein assays, there is no report in the literature describing interference of these types of antibodies in immunoassays for TDM.

An interesting case study showed that the IgM antibodies to Escherichia coli in a septimea patient's serum showed heterophilic antibody like interference in many sandwich assays (25).

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