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Tolerance can be defined as the need for increasing doses of a drug over time to maintain the same effect achieved at previous lower doses. The body becomes tolerant to the effects of meth within minutes.7, 9 Remember, after smoking or injecting meth, the user experiences an intense explosion of dopamine, experienced as a euphoric high. Meth users try to maintain that high by using ever-increasing quantities of meth, or by switching to a faster-acting way of using, such as moving from snorting to injecting. Some abusers go on a binge known as a "meth run," injecting a gram (1,000 mg) of meth every two to three hours until the user runs out of the drug or is too intoxicated to continue.2 This can last for several days or even weeks. To compare, a medicinal dose of legal methamphetamine, Desoxyn, is about five to 15 milligrams (mg) per day. This means a user on a meth run is taking approximately 800 times the therapeutic dose of meth each day.2, 9 (Approximate illegal dose of 1,000 mg times every three hours [eight times a day] divided by an average of 10 mg, the therapeutic dose of meth.)

There are two ways to understand how a person can develop tolerance to meth.9 First, methamphetamine depletes the neurotransmitter norepinephrine from the body. As the brain's supply of norepinephrine dwindles, the user needs more and more meth to maintain a consistent high. This tolerance can happen after only one or two doses of meth. Secondly, ketosis causes tolerance. Ketosis is a by-product of not eating for long periods of time. Not only does this produce very bad breath, but when a person stops eating, it changes the body's metabolism, causing the urine to become more acidic. As we learned in Chapter Three, the more acidic the urine, the more methamphetamine is excreted in the urine. This causes the user to need more and more meth to achieve the same high.


Many meth users go on "binge and crash" runs for three to five days and then crash, sleeping for one or two days. During these binges, users often become agitated and feel "wired." Their behavior becomes unpredictable. They may be friendly and calm one moment, then angry and terrified the next, prone to out-of-control rages, delusions, paranoia, and violence. This phase of the meth high is called tweaking. Tweakers become hyperactive, obsessed with details, and intensely focused, and feel compelled to repeat meaningless tasks, such as taking apart and reassembling clocks, stereos, and other types of machinery. The release of high amounts of the body's fight-or-flight chemicals, epinephrine (adrenaline) and norepinephrine, is thought to cause this tweaking effect in a meth user.

Tweakers may also have a strong sensation of bugs crawling beneath their skin, a disorder known medically as formication but more often referred to as "crank bugs." Meth users can pick obsessively at these invisible "bugs," creating unsightly oozing sores and scabs on their faces and bodies.5, 7 11 24

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  • irvin
    Can I get a tolerance to meth?
    2 years ago
  • guido
    How to bypass meth tolerance?
    2 years ago
  • Severi
    How to lower meth tolerance?
    2 years ago
  • james
    Can you build a tolerance to meth amphetamine?
    1 year ago
  • oscar fiorentino
    What is the tolerance for meth test of 500 limit?
    1 year ago
  • Edmonda
    How much meth can a person with high tolerance take per day?
    1 year ago
  • mehret
    Can your body build a tolerance to meth?
    1 year ago
  • coy
    Can a meth user develop tolerance?
    12 months ago
  • bilbo hornblower
    How much is 1000mg of methamphetamine?
    9 months ago
  • lavinia
    How long to reduce meth tolerance?
    9 months ago
  • david
    Does smoking meth increase narcotic tolerance?
    7 months ago
  • maisy mitchell
    How many milligrams of potassium should I take after smoking meth amphetamines for the entire day?
    6 months ago
  • Eeva
    How many slams is to high toleranc meth?
    6 months ago
  • daniel
    How quick do you build a tolerance to meth?
    5 months ago
  • Lamorac Labingi
    What in the brain that causes one to become tolerant to a drug?
    4 months ago
  • JOAN
    Is a tolerance built up for crystal meth?
    3 months ago
  • richard
    How long does it take to become dependent on meth?
    18 days ago
  • sven
    How long does it take to become physically dependent on meth?
    14 days ago
  • medhane dahlak
    How to make your meth tolerance go down?
    14 days ago
  • kimi kolkkala
    What is the tolerance level of meth users?
    10 days ago

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