We have recently published findings suggestive of brain morphological changes in marijuana smokers (Wilson et al., 2000). MRI was utilized to determine brain volumes for gray, white and lateral ventricles, and PET was used to determine
CBF in 57 subjects with a history of marijuana use. The relationships of three variables - age at first use, duration of use (defined as current age minus age at first use) and current level of use - to brain volume measures (whole brain, gray matter, white matter and lateral ventricle volumes expressed as a percentage of whole brain volume), global CBF and body size were evaluated.
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