Exploration Of Euphoriant And Antidepressive Effects Of

When Condrau (21) proposed the use of LSD for depression on the basis of its euphoriant effect on some subjects, he followed the model of opium treatment. He administered small and progressively increasing daily doses of LSD to depressive patients and expected alleviation of depression and positive changes in mood. According to Condrau's statement, the results were not convincing and the observed changes did not exceed the limits of the usual spontaneous variations. He also noticed that LSD medication usually resulted in deepening of the pre-existing mood rather than consistent euphorization.

Similar results were reported by other authors who used either Condrau's model of daily medication with LSD in depressive patients or isolated administrations of medium dosages of LSD with the intention to dispel depression. Negative or inconclusive clinical experiences have been reported by Becker, (8) Anderson and Rawnsley, (3) Roubicek and Srnec, (89) and others.

By and large, the results of this approach to LSD therapy did not justify continuation of research in this direction. Clinical studies clearly indicated that LSD does not per se have any consistent pharmacological effects on depression that could be therapeutically exploited, and this approach has been abandoned.

0 0

Post a comment