Inflammatory Bowel Disease - A Holistic Perspective

The IBS Miracle

Today to Discover: My unique holistic system to immediately get symptomatic relief and completely cure your condition within 3 to 8 weeks using my powerful 100% natural system. The horrible truth about conventional Ibs treatments. A list of the original hidden research papers (together with all the details you need to locate them yourself) published by scientists and MDs reporting how they cured Ibs using natural methods so you'll see that my system is backed by scientific evidence! 78 different scientific sources to be exact! How simple over the counter products will immediately reduce cramps and abdominal pain. The dietary changes you should make to live an Ibs-free life. How to make your body combat Ibs and re-balance itself. The link between lifestyle and Ibs. The specific foods that trigger Ibs symptoms. Foods that are marketed as being ery healthy that will actually cause your Ibs to get worse. Herbs that are extremely potent in stopping diarrhea, constipation and gas. Simple alternative treatments that will cure your Ibs faster than you ever thought possible. I will show you step by step how to do this. The food items you have to include in your diet if you want to get rid of your Ibs fast. The food items you should limit if you want to get rid of Ibs. Convenient printable charts that will tell you exactly the foods to avoid and the foods to include. The secret 100% natural remedies that you should use, and are guaranteed to make a dramatic impact on your Ibs condition in just a few days! Read more...

The IBS Miracle Summary

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Contents: 60 Page EBook
Author: James Walden
Official Website: theibsmiracle.com
Price: $37.00

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Highly Recommended

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Irritable Bowel Syndrome Relief Secrets

Here is just some of what you will discover inside Irritable Bowel Syndrome Relief Secrets: What causes Ibs this information may surprise you. 4 ways to improve your immune system and reduce your symptoms follow these tips and you'll put yourself on the fast track to reclaiming control of your life. The similarity in symptoms between Ibs and having a sensitive, reactive colon and what this means as far as the treatment you should pursue. Why stress is a catalyst for Ibs symptoms and what you can do to begin reducing your symptoms immediately. The common symptoms of Ibs, including the four main ones and how to manage them all effectively. How Ibs is usually diagnosed and whether the two main types of tests doctors usually run are actually effective or not. Effective strategies you can use to treat your Ibs symptoms and even eliminate them for good. Practical exercises for you to do that lead you step-by-step through the information revealed in Irritable Bowel Syndrome and Treatments and ensure that you stay on track to gaining control of your Ibs and improving the quality of your life! Read more...

Irritable Bowel Syndrome Relief Secrets Summary

Official Website: www.natural-irritable-bowel-syndrome-relief.com
Price: $37.77

Drugs for chronic inflammatory bowel disease

Inflammatory bowel disease (1BD) often affects young adults, and young women with IBD may become pregnant. Several earlier retrospective studies suggest that the rates of prematurity, fetal loss, and congenital malformations in IBD approximate the incidence of these findings in the normal population (review by Katz 2001). Recent population-based studies, however, have demonstrated an increased risk of preterm delivery and have documented neonates born to mothers with IBD to have lower birth weight and to be small for gestational age (Dominitz 2002, Norg rd 2000, Fonager 1998, Kornfeld 1997). Two studies also reported an increased risk of malformations, contradicting earlier findings (Norg rd 2003, Dominitz 2002). Disease symptoms and activity play a dominant role in determining pregnancy outcome. Active inflammatory bowel disease in pregnancy has been associated with low birth weight, higher rates of spontaneous abortion, prematurity, and perinatal complications. Therefore, optimal...

Inflammatory Bowel Disease

Inflammatory bowel disease is characterized by oxidative and nitrosative stress, leukocyte infiltration, and up-regulation of proinflammatory cytokines. Ukil et al. recently investigated the protective effects of curcumin on inflammatory bowel disease induced in a mouse model. Pretreatment of mice with curcumin for 10 days significantly ameliorated the appearance of diarrhea and the disruption of colonic architecture 78 . Curcumin is able to attenuate colitis in the dinitrobenzene sulfonic acid-induced murine model of colitis 79 . When given before the induction of colitis, it reduced macroscopic damage scores and NF-kB activation, reduced myeloperoxidase activity, and attenuated the dinitrobenzene-induced message for IL-10. Thus, curcumin attenuates experimental colitis through a mechanism that also inhibits activation of NF-kB and effects a reduction in the activity of p38 MAPK. The authors proposed that this agent might have therapeutic implications for human inflammatory bowel...

Agents used for chronic inflammatory bowel diseases

Sulfonamides, 5-aminosalicylic acid, glucocorticoids (e.g. oral prednisolone or locally applied budesonidc), cytostatics (methotrexate, 6-mercaptopurine, thioguanine), immunosuppressive drugs (aza-thioprine), and, recently, monoclonal antibodies (e.g. infliximab) are used to treat chronic inflammatory bowel disease, ulcerative colitis, and Crohn's disease. Recommendation. For chronic inflammatory bowel diseases, mesalazine is the drug of choice. Olsalazine may also be used for appropriate indications. If the sulfonamide effect of sulfasalazine is particularly desirable, this drug may also be used. Corticoids may be administered both rectally and systemically during breastfeeding. Methotrexate should not be prescribed. For immunosuppressive medications used for chronic inflammatory bowel disease, see Chapter 4.10.

Possible Mode of Action of Hp

Acteoside is rarely discussed with regard to the pharmacology of Hp. It is present in Hp extracts in amounts similar to that of harpagoside 10 , which is the more characteristic and most often discussed constituent of Hp. Acteoside and acety-lated derivatives are present in many plants and have been identified as an active ingredient of, for example, Plantago lanceolata. In its isolated form, acteoside exhibits an anti-inflammatory property in vitro due to its antioxidant effects 41-44 , which also include inhibition of eicanosoids production 45, 46 . Also in in vivo models of inflammation, it down-regulates expression of ICAM-1 47, 48 , which is involved in leucocyte recruitment within inflamed tissue and of iNOS expression 49 . More recently, it has been shown that parenteral acteoside exerts significant dose-dependent anti-inflammatory effects in a rodent model of inflammatory bowel disease (dextran sulphate sodium-induced colitis in mice) when administered after induction of...

Purinederived antimetabolites purine antagonists

6-Mercaptopurine is a purine analog, which acts as an inhibitor of nucleic acid synthesis (cf. azathioprine AZA, a pro-drug of 6-MP). Until now, no specific malformation syndrome has been described. 6-MP is also used as an immunosuppressive, for example for chronic inflammatory bowel disease (IBD). The plasma half-lives of 6-MP and AZA of 1-3 hours are short, but the half-life of the cytostatic active metabolite, the thioguanine nucleotide, is 3-13 days. The mode of action and metabolic transformation of 6-MP vary

AGlucosidase Inhibitors

The a-glucosidase inhibitors are contraindicated in patients with a hypersensitivity to the drug, diabetic ketoacidosis, cirrhosis, inflammatory bowel disease, colonic ulceration, partial intestinal obstruction or predisposition to intestinal obstruction, or chronic intestinal diseases. Acarbose and miglitol are used cautiously in patients with renal impairment or pre-existing gastrointestinal (GI) problems such as irritable

Contraindications Precautions And Interactions

The glucocorticoids are administered with caution to patients with renal or hepatic disease, hypothyroidism, ulcerative colitis, diverticulitis, peptic ulcer disease, inflammatory bowel disease, hypertension, osteoporosis, convulsive disorders, or diabetes. The glucocorticoids

Advanced Formulations Targeting the Large Intestine

The treatment of diseases such as inflammatory bowel disease (including ulcerative colitis and Crohn's disease), has lead to the need for colon-targeted drug delivery. In addition systemic absorption from the colon offers advantages over absorption from the intestines including

Intestinal Inflammation

Many patients with inflammatory bowel disease anecdotally report that they experience relief by smoking marijuana (Di Carlo and Izzo 2003). Furthermore, some cannabinoid-based preparations are already being evaluated in clinical trials for the treatment of inflammatory bowel disease (Di Carlo and Izzo 2003). Experimental evidence indicates that the ECS, via CB1 activation, mediates protective pathophys-iological signals counteracting intestinal inflammatory responses. Enhancement of the cannabinoid signalling, as revealed by the increased expression of enteric CB1 receptors, has been observed following intestinal inflammation induced by a number of irritants, including intra-colonic dinitrobenzene sulfonic acid (DNBS) (Massa et al. 2004), oral croton oil (Izzo et al. 2001b) and intraperitoneal acetic acid (Mascolo et al. 2002). Massa et al. (2004) showed that colitis induced by intra-colonic DNBS was more severe in CB1-deficient mice than in wild-types lit-termates, while...

Thiopurine Methyltransferase

Thioprine, thioguanine, and 6-mercaptopurine are thiopurine drugs that are used to treat acute lymphoblastic leukemia, autoimmune disorders, inflammatory bowel disease, and organ transplant recipients. These drugs are metabolized by the genetically polymorphic enzyme thiopurine methyltransferase (TPMT). Thiopurines are very useful drugs, but they have a relatively narrow therapeutic index, with life-threatening myelosuppression as a major toxicity (72).

See also Cytostatic and immunosuppressant drugs General Information

Tioguanine is an analogue of the physiological purines, gua-nine and hypoxanthine, and is a purine antimetabolite. It is incorporated into DNA and RNA, resulting in a variety of cytotoxic effects. It has been used to treat hematologi-cal malignancies, psoriasis, and more recently, inflammatory bowel disease, such as Crohn's disease. Its main adverse effects are liver damage and hemotoxicity. Among 111 patients taking tioguanine for inflammatory bowel disease, 29 had laboratory abnormalities, most commonly rises in liver enzymes and reduced platelet counts (1). Of the patients who underwent liver biopsy, there was nodular regenerative hyperplasia in 76 of those with laboratory abnormalities and 33 of those without.

Epidemiological Data

Some authors 64 explored the use of herbs in children with attention-deficit-hyperactivity disorder or depression the prevalence of herbal therapy among 117 patients was 20 and, interestingly, the children's psychiatrists and paediatricians were not aware of such use. Ginkgo biloba, Echinacea and St John's wort were the herbs most frequently given. A survey performed in three paediatric gastroenterological centres reported that 14 of 208 children with inflammatory bowel disease used herbal medicines to treat this condition, in addition to conventional therapies 65 . In Australia, 29 of 174 asthmatic children on therapy with bronchodilators and disodium cromoglycate or inhaled steroids had used herbal preparations to ease their symptoms 66 .

Cumulative index of special reviews Annuals 1625

18.99, 20.86, 21.96, 22.108, 23.114 gastrointestinal toxicity, prevention, 19.93 inflammatory bowel disease, 25.131 nephrotoxicity, 18.100, 20.89, 24.120 topical, 18.163 supplements, 20.322 inflammatory bowel disease, NSAIDs, 25.131 intestinal motility, macrolides, 18.269 intussusception, Rotashield, 23.354

Selective immunosuppressants

In the prospective study, the outcome of 49 children of 37 liver-transplanted mothers was analyzed (Jain 2003). Two premature babies and one child with multiple anomalies died one newborn had a unilateral cystic kidney without urine production. In a retrospective analysis of 100 pregnancies with 68 live-born children, there were four with different malformations (Kainz 2000). Retrospective cases report premature twins of 32 weeks' gestation. Both suffered from cardiomyopathy, of which one of them died (Vyas 1999). Among nine tacrolimus-exposed pregnancies, there were two with a small ventricular septal defect (Nagy 2003). An otherwise healthy premature baby who was exposed in utero to tacrolimus and mycophenolate mofetil demonstrated hypoplastic fingernails and short fifth fingers on both hands (Pergola 2001). There are rare case reports on the use of tacrolimus during pregnancy for other indications, such as refractory inflammatory bowel disease (Baumgart 2005).

Surveillance of adverse events following immunization

Currently, in many highly developed countries in which the incidences of dangerous infectious diseases have been markedly reduced through immunization, there are controversial discussions about the balance of benefits and harms in immunization. Vaccine adverse events, both those caused by vaccines (that is true adverse reactions) and those associated with immunization only by coincidence, become more visible than the natural disease. Not surprisingly, vaccine safety concerns have become increasingly prominent in such successful immunization programs. Vaccines have been spuriously linked by various researchers to asthma, autism, diabetes, inflammatory bowel disease, multiple sclerosis, permanent brain damage, and sudden infant death syndrome (SIDS). Modern communication is providing even more penetrating ways of communicating messages on the subject through the World Wide Web. The result is a formidable challenge to immunization service providers. Neil Halsey, head of the Institute for...

Teratogenicity

The consequences of paternal mercaptopurine exposure on the outcome of pregnancies have been retrospectively studied in 57 men with inflammatory bowel disease 23 men had fathered 50 pregnancies and had taken mercaptopurine before conception of these, 13 pregnancies were conceived within 3 months of paternal mercapto-purine use (group 1A) and 37 pregnancies were conceived at least 3 months after paternal mercaptopurine withdrawal (group 1B) the other 34 men, who fathered 90 pregnancies, had not been exposed to mercaptopurine before conception (group II) (81). Of the 140 conceptions, two resulted in congenital anomalies in group 1A, whereas there were no congenital anomalies in the other groups. One child had a missing thumb, and the other had acrania with multiple digital and limb abnormalities. The overall number of complications (spontaneous abortion and congenital anomalies) was significantly higher in group 1A (4 13) compared with both group IB (1 37) and group II (2 90). Although...

Gastrointestinal

Celecoxib reportedly exacerbated inflammatory bowel disease in two patients (5). The possible association of NSAIDs with inflammatory bowel disease is a matter of controversy (SEDA-25, 131), and there is little clinical experience with the selective COX-2 inhibitors. Coxibs should not be prescribed for patients with chronic inflammatory bowel disease until more experience has accumulated.

Ischemic colitis

A possible risk of glucocorticoid treatment of ulcerative colitis is the development of toxic megacolon or colonic perforation. A change from ulcerative colitis to Crohn's disease may have been induced by prolonged treatment with glucocorticoids (SEDA-19, 376) (130). This case provides further evidence for the view that ulcerative colitis and Crohn's disease may represent a continuous spectrum of inflammatory bowel disease and raises the possibility that reduced polymorphonuclear leukocyte function caused by glucocorticoids may have provoked the development of granulomata.

Polyethylene glycol

Polyethylene glycol is a high molecular weight inert molecule that is commonly combined with electrolytes (potassium chloride, sodium bicarbonate, sodium chloride, and sodium sulfate) in colonic lavage systems. Owing to the osmotic properties of these solutions, there is little absorption or secretion of electrolytes or water, although small amounts of polyethylene glycol and sulfates have been detected in the urine of healthy patients and higher concentrations in the urine of patients with inflammatory bowel disease (5). Common adverse effects of solutions containing polyethylene gly-col and electrolytes include nausea, abdominal fullness, and bloating in up to 50 of patients. These solutions are contraindicated in patients with gastric outlet obstruction or gastroparesis, gastrointestinal obstruction or perforation, ileus, or toxic colitis (6).

Sulfasalazine

A meta-analysis of 23 randomized clinical trials assessing the efficacy and tolerance of smooth muscle relaxants in irritable bowel syndrome has shown that these drugs are superior to placebo (65C). Six drugs were analysed cimetropium bromide (five trials), hyoscine butyl bromide (three trials), mebeverine (five trials), otilium bromide (two trials), and trime-butine (four trials). There was no overall significant difference in the frequency of adverse effects compared with placebo. 10. Camilleri M, McKinzie S, Pardi DS, Burton D, Thomforde GM. Gender-related differences in slowing colonic transit by a 5-HT3 antagonist in subjects with diarrhea-predominant irritable bowel syndrome. Am J Gastroenterol 2001 96 2671-6. 11. Wright RA, Bagby B, Decker C, Gordon S, Jhingran P, Carter E. Alosetron controls bowel urgency and provides global symptom improvement in women with diarrhea-predominant irritable bowel syndrome. Am J Gastroenterol 2001 96 Suppl 2662-70. 12. Wolfe SG, Chey WY,...

How To Win Your War Against Irritable Bowel Syndrome

How To Win Your War Against Irritable Bowel Syndrome

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