How To Treat Hypothyroidism Naturally

The Hypothyroidism Solution Program

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Hypothyroidism Solution Summary


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Hypothyroidism triiodothyronine T3 and thyroxine T4

Pregnant women with hypothyroidism have a higher risk of complications Glinoer 1997), and hypothyroidism during pregnancy can impair the mental development of the child. In particular in relation to iodine deficiency, this has been understood for a long time. According to a recent study on 60 hypothyroid women (whose disease was only diagnosed after 12 weeks of pregnancy), hypothyroidism impaired the mental and motor capacities of their children, who were tested at the age of 2 years compared to children of euthyroid or only discrete hypothyroid women during pregnancy (Pop 2003). Haddow (1999) draws similar conclusions from his study on 60 children aged 7-9 years. Their mothers only suffered from discrete hypothyroidism during pregnancy. Based on these results, hypofunction of the thyroid should be diagnosed and treated for the benefit of Lhe developing unborn child. Regarding the risk of neonatal hypothyroidism after maternal thyrostatic therapy during pregnancy, sec section 2.15.7....

Thyroid Hormone and Antithyroid Drugs

Diseases associated with thyroid glands are the result of either excess production of thyroid hormone (hyperthyroidism), or its insufficiency (hypothyroidism). Both cases can result in a goiter. Thyroid hormones are used clinically primarily to treat hypothyroidism. This disease is characterized by a decrease or lack of endogenic thyroid hormone secretion. When originating in childhood, it can be clinically described as cretinism (infantile hypothyroidism), and in adults as myxedema (adult hypothyroidism), which is expressed in a loss of mental or physical ability to work, suppression of metabolic processes in the body, and edema. Since thyroid function cannot be restored, the clinical effect is only visible when using thyroid hormones. Using thyroid hormones in hypothyroidism is a replacement therapy that does not correct the disease itself. Currently, a very small number of various drugs such as drugs of animal thyroid glands and synthetic drugs are used to treat hypothyroidism....

Antithyroid drugs

Cardiovascular It is well recognized that worsening of angina, precipitation of acute my-ocardial infarction, and even death in subjects with underlying coronary artery disease can occur, albeit uncommonly, when thyroxine replacement is begun. This recognition has led to the recommendation, especially in those known to have heart disease and with severe and longstanding hypothyroidism, that thyroxine should be introduced gradually (1R). In two cases of hypothyroidism myocardial infarction occurred at the start of thyroxine therapy in the absence of evidence of significant coronary artery disease (2A). A 58-year-old man with a previous smoking history and a history of hypertension was severely biochemically hypothyroid (serum TSH 221 mU l) and was given thyroxine, initially in a low dose (25 g day), increasing to 100 ig day after 2 weeks. A month later he sustained a subendo-cardial myocardial infarction associated with only minor abnormalities on coronary angiography. A 61-year-old...

General Information

Ascophyllum nodosum, Fucus vesiculosus, Fucus serra-tus, Laminaria species, and Macrocystis pyrifera). As kelp contains iodine, it occasionally produces hyperthyr-oidism (1), hypothyroidism, or extrathyroidal reactions, such as skin eruptions. It can also contain contaminants such as arsenic, and bone marrow depression and autoimmune thrombocytopenia have been described in consequence (2).

Drug Metabolism and Clearance in Pregnancy

During pregnancy, the thyroid is hyper-stimulated resulting in changes in thyroid hormone concentrations. Gestational age-specific reference intervals are now available for thyroid function tests. Knowledge of expected normal changes in thyroid hormone concentrations during pregnancy allows individual supplementation when needed (98). Hypothyroidism is common in pregnancy, and therapeutic drug monitoring of antithyroid drugs is important. Consistently lower serum concentrations of propy-lthiouracil were observed in pregnant women compared with that in non-pregnant women (99).

Second Generation Effects Teratogenicity

In one child there was evidence of mental delay, hypotonia, hypertelorism, and micrognathia (SEDA-20, 176), although the authors thought that the link between amiodarone and neurotoxicity was speculative. However, there has also been a retrospective study of 10 children who were exposed to amiodarone during pregnancy, compared with matched controls (218). There was no change in IQ score, but the children who had been exposed to amiodarone had impaired expressive language skills and one child had global developmental delay. However, most of the mothers were not concerned about their children's development, and so any effect of amiodarone on neurological development was probably small. One child had transient neonatal hypothyroidism, which responded to a short course of thyroxine another had mild transient neonatal hyperthyroidism in neither case was there any difference in development from the other children who had been exposed to amiodarone. One child was born with a congenital jerk...

Other features of the patient

The apparent volume of distribution of digoxin is reduced in hypothyroidism (145) and in renal insufficiency (146). This leads to increased plasma concentrations after a loading dose and hence an increased risk of toxicity, but does not affect the plasma concentration at steady state. The opposite occurs in hyperthyroidism. Thyroid disease Apart from the pharmacokinetic differences in thyroid disease (mentioned above), there may also be changes in tissue responsiveness, with reduced sensitivity in hyperthyroidism and the reverse in hypothyroidism (145). The reasons for these changes are not known, but

Educating the Patient and Family

For increasing growth (height) with the child's parents or guardians. If the drug is to be given at bedtime and not in the outpatient clinic, the nurse instructs the parents on the proper technique to administer the injections. The parents are encouraged to keep all clinic or office visits. The nurse explains that the child may experience sudden growth and increase in appetite. The nurse instructs the parents to report lack of growth, symptoms of diabetes (eg, increased hunger, increased thirst, or frequent voiding) or symptoms of hypothyroidism (eg, fatigue, dry skin, intolerance to cold).

Pregnancy Category C

Levorphanol can cause dangerous and even fatal breathing difficulty. For that reason medical personnel are supposed to carefully adjust dosage to a patient's individual needs rather than depend upon customary amounts of the drug being safe. It is supposed to be used with special caution in patients with asthma, low thyroid function, urinary difficulty, or an enlarged prostate. Wariness is also prudent when using the substance to reduce heart pain, because the drug's influence on cardiac function has not been confirmed. The substance can lower blood pressure and may produce nausea, vomiting, and constipation. Levorphanol can make users woozy and harm skills needed for operating a car or other dangerous machinery. Although levorphanol is a depressant in humans, it increases leg activity in ponies an effect that may not have escaped notice by persons seeking ways to improve the animals' performance in races.

Contraindications Precautions And Interactions

The glucocorticoids are administered with caution to patients with renal or hepatic disease, hypothyroidism, ulcerative colitis, diverticulitis, peptic ulcer disease, inflammatory bowel disease, hypertension, osteoporosis, convulsive disorders, or diabetes. The glucocorticoids

Novel Uses for RXRActive Compounds

In intestinal cells, this protein transports cholesterol into the lumen of the intestine, effectively reducing cholesterol uptake by the cell and ultimately lowering blood cholesterol levels. In the case of agonists, this effect is amplified because RXR agonists (rexinoids) also decrease bile acid secretion through the activation of RXRFXR heterodimeric complexes (243,244) (Table 7.4). Because bile acids are important vehicles for cholesterol dissolution and gener- ally promote cholesterol absorption in the gut, the effect of RXR-mediated induction of ABCl expression has an even more dramatic effect on serum cholesterol levels. In addition, the ABCl protein mediates cholesterol efflux from macrophages that contribute to atherosclerotic processes (240). The development of additional RXR-selective ligands will clearly be at the forefront of retinoid biology in the future. However, there are problems with rexi-noid therapy, including disruptions in...


Thyroid hormones are used as replacement therapy when the patient is hypothyroid. By supplementing the decreased endogenous thyroid production and secretion with exogenous thyroid hormones, an attempt is made to create a euthyroid (normal thyroid) state. Levothyroxine (Synthroid) is the drug of choice for hypothyroidism because it is relatively inexpensive, requires once-a-day dosages, and has a more uniform potency than do other thyroid hormone replacement drugs. Myxedema is a severe hypothyroidism manifested by lethargy, apathy, memory impairment, emotional changes, slow speech, deep coarse voice, thick dry skin, cold intolerance, slow pulse, constipation, weight gain, and absence of menses. Thyroid hormones are also used in the treatment or prevention of various types of euthyroid goiters (enlargement of the thyroid gland), including thyroid nodules, subacute or chronic lymphocytic thyroiditis (Hashimoto's), and multinodular goiter and in the management of thyroid cancer. The...

Promoting an Optimal Response to Therapy

Thyroid hormones are administered once a day, early in the morning and preferably before breakfast. An empty stomach increases the absorption of the oral preparation. Levothyroxine (Synthroid) also can be given intravenously and is prepared for administration immediately before use.

Organs and Systems Cardiovascular

Permanent hypothyroidism associated with vitiligo was reported in a woman treated with interleukin-4 for meta-static malignant melanoma (SEDA-20, 336). Vitiligo associated with permanent hypothyroidism was reported in a woman treated with interleukin-4 for meta-static malignant melanoma (SEDA-20, 336).

Iodinecontaining medicaments

Iodine must be present in the normal diet to prevent iodine-deficiency goiter or cretinism, and iodine deficiency-related disorders are still a worldwide (although preventable) group of diseases that affect about 150 million people in at least 40 countries. The WHO sponsored a program to control these disorders by the year 2000 (1,2), and since 1990 there has been a remarkable progress in prevention of iodine deficiency disorders. However, by the year 2000 one-third of the population affected by iodine deficiency disorders still did not have access to iodized salt (3). Scepticism about the introduction of population-wide programs to prevent iodine-deficiency disorders is occasionally encountered in regions of mild iodine deficiency, especially in Europe (4). The main arguments against introduction of iodized salt are a temporary rise in the incidence of hyperthyroidism (5), a possible increase in the incidence of Graves' disease, and the fact that the remission rates with antithyroid...

General adverse effects

It has been estimated that in 1994 some 1.5 billion people in 118 countries were at risk of iodine deficiency, this being regarded as the world's most significant cause of preventable brain damage and mental retardation. Fortification of all salt for animal and human consumption has been chosen as the preferred method for the prevention of iodine deficiency disorders, and this approach is proving effective in reducing the incidence of such disorders. However, iodine supplementation is not without risks, which have been discussed (20) and which include allergic reactions and iodine-induced hyperthyr-oidism. It has been clearly shown that the benefits of iodine deficiency outweigh the risks on a population basis, but it is nevertheless evident that introduction of iodine supplementation is associated with clinical problems in individual subjects. Iodine excess can induce hyperthyroidism or hypothyroidism (SEDA-12, 355) (SEDA-13, 378). Pharmacological amounts of iodine induce only a...

Second Generation Effects Pregnancy

Iodine readily crosses the placenta, and the fetal concentration usually exceeds the maternal concentration. The placenta does not seem to have a regulating transfer mechanism, implying that excess maternal intake of iodine will also expose the fetus to iodine intoxication. This usually results in hypothyroidism and development of goiter. Such goiters may become very large and even create obstetrical problems during delivery or mechanical compression during early postnatal life (SEDA-4, 295) (SEDA-5, 328). In neonates iodine excess is a well-known cause of transient hypothyroidism. Iodine-containing antiseptics should therefore be avoided in both the delivery room and the neonatal ward. A similar warning against the use of iodine or iodine-containing drugs applies during lactation since iodine is actively secreted in milk.

Iodinecontaining contrast media

The amount of free iodine in the contrast medium is less than 0.1 of the total. The amount of the free iodide depends on the compound, and can increase during storage. The Contrast Media Safety Committee of the European Society of Urogenital Radiology reviewed the literature and developed guidelines (Webb 2005). Free iodide can reach the fetal thyroid and be stored there. The danger with iodine in excess is transient fetal hypothyroidism, particularly from the twelfth week of

Susceptibility Factors Age

Hypothyroidism in neonates has been related to the use of small doses of iodine as an antiseptic. The high vulnerability of the neonatal thyroid is a reason for avoiding povidone-iodine for care of the umbilical stump or omphaloceles (SEDA-11, 488) (SEDA-12, 585) (39). Serum TSH and thyroxine concentrations have been measured 57 days after birth in 365 healthy newborns whose umbilical stump had been treated with 10 povi-done-iodine (40). The prevalence of high TSH concentrations was significantly higher in this group than in the general population (3.1 versus 0.4 ), as was the rate of transient hypothyroidism (2.7 versus 0.25 ). All the children were normal when retested 1 week later. Transient hypothyroidism due to skin contamination with povidone-iodine occurred in a neonate with an omphalocele (41). The postnatal iodine overload, measured as urinary iodine concentration, has been studied in ill neonates after the cutaneous application of povidone-iodine (0.96 I2 Betadine) (SEDA-11,...

Iodine And The Iodides

Thyroid disease and the heart. Heart 2000 84 455-60. 2. Kohno A, Hara Y. Severe myocardial ischemia following hormone replacement in two cases of hypothyroidism with normal coronary arteriogram. Endocr J 2001 48 565-72. 7. Andres E, Kurtz JE, Perrin AE, Dufour P, Schlienger JL, Maloisel F. Haematopoietic growth factor in antithyroid-drug-induced agranulocytosis. Q J Med 2001 94 423-8. 8. Fukata S, Kuma K, Sugawara M. Granulo-cyte colony-stimulating factor (G-CSF) does not improve recovery from antithyroid drug-induced agranulocytosis a prospective study. Thyroid 1999 9 29-31.

Thyroid stimulating hormone TSH thyrotropin SED141489

Recombinant human TSH stimulates iodine uptake, and this facilitates the diagnosis and treatment of recurrent disease or metastases in the follow-up of differentiated thyroid cancer. It is used as an alternative to thyroid hormone withdrawal, to avoid symptomatic hypothyroidism (58r). Headache and nausea occur in 6-40 of

Congestive Heart Failure

About 15 of patients on long term treatment will experience toxicity at some time. Severe overdoses can lead to hyponatremia and hyperkalemia due to cellular effects. Hypokalemia or hypercalcemia both increase the risk of digitalis toxicity. Old age or Hypothyroidism also increases sensitivity to standard doses.

Thyroid hormones and thyroid receptor antibodies

L-thyroxine is used as a substitute in cases of hypothyroidism (at least 1 ng kg daily for adults), and, for this reason, is not problematic. The normal thyroid content of mother's milk is approximately 1 ng 1. An infant takes in about 0.15 ig kg in 24 hours this represents about 1 of a substitution dosage at this age (lOpg kg daily). This amount does not influence the thyroid function of a healthy infant. The same applies for treatment (substitution) of a maternal hypoparathyroidism. Of course, this also means it has no therapeutic effect in case of a congenital hypo- or athyroidism. This has to be taken into account in case of extremely premature newborns with a higher risk for hypothyroidism. Neither breast milk nor formula contains enough thyroxine for substitution (van Wassenaer 2002). Thyroid receptor antibodies (TRAb) can result in transient neonatal thyroid disease by transfer through milk from mothers treated for thyrotoxicosis, Serum TRAb concentration in neonates decrease...

Drug Administration Drug dosage regimens

There are two general patterns of use of antithyroid drugs monotherapy with progressive reduction in dosage during recovery from hyperthyroidism and a higher dosage of antithyroid drugs complemented by thyroid replacement therapy to avoid hypothyroidism. There is no convincing evidence for a better short-term or long-term control of Graves' disease with either form of therapy, but combination therapy followed by monotherapy with levothyroxine increased the remission rate substantially. The administration of levothyroxine during antithyroid drug treatment reduces both the production of antibodies to TSH receptors and the frequency of recurrence of hyperthyroidism (90). During combination therapy with propylthiouracil and levothyroxine in normal therapeutic doses the inhibition of the conversion of T4 to T3 is of no importance. A single daily dose of antithyroid drugs cannot completely block iodine organi-fication but can nevertheless control most cases of hyperthyroidism. Such therapy...

History and Recent Therapeutic Uses

Similar bystander effect could be obtained by other apoptosis-inducing molecules such as Fas ligand (FasL). FasL and its receptor Fas are membrane proteins, which on mutual interaction initiate an apoptotic signal in Fas-bearing cells. pDNA could be used to deliver these apoptosis-inducing gene to initiate killing of transfected and non-transfected surrounding cells. On direct injection of FasL-en-coding pDNA vector into the inflamed thyroid pathogenic lymphocytes were inhibited to enter into thyroid leaving the already-infiltrated T-cells dead. Thus, FasL expressing in thyroicytes might lead to potential remedial therapy for the experimental autoimmune thyroiditis (EAT).

Family Capparaceae A L de Jussieu 1789 nom conserv the Caper Family

Glucosinolates are suspected to be responsible for hypothyroidism, but their presence in the diet could have a protective effect against colon cancer. About 20 species of plants classified within the family Capparaceae are used medicinally in the Asia-Pacific. These are often used as counter-irritant remedies.

Hyperthyroidism and thyrostatics

An uncontrolled hyperthyroidism of a pregnant woman is a risk for the outcome of pregnancy and the fetus fetal growth retardation, pre-eclampsia, prematurity, and intrauterine death or stillbirths occur more often (Glinoer 1997). In cases of Graves' disease or Hashimoto thyroiditis - the latter usually results in hypothyroidism - the maternal auto-antibodies should be tested at the beginning of pregnancy and early in the third trimester. A high concentration, especially of TSH-receptor antibodies (TRAb), is often correlated with a diaplacental transfer of these antibodies. It is estimated that 1-2 of pregnancies with Graves' disease result in a transient hyperthyroidism of the fetus or newborn, respectively (Carrol 2005). A recently published prospective study on 115 pregnant women reports a much higher rate of 12.6 of fetal neonatal hyperthyroidism (Rosenfeld 2005). 9.5 of in utero PTU-exposcd children developed hypothyroidism and 5.4 also developed goiter. Not all hypothyroid...

Antiseptics and disinfectants

When povidone iodine is used as a local disinfectant on intact skin, on wounds and on the mucosa as well as in body cavities, iodine transfer to the fetus must be assumed. This can lead to functional disturbances in the fetal thyroid gland. The intake of iodine from a vaginal douche during labor can lead to a temporary TSH-increase in the newborn's blood - a sign of transient hypothyroidism (Weber 1998). This should be considered in the interest of the undisturbed thyroid status necessary for central nervous system differentiation. Retrospective evaluation of children born to mothers who applied iodine vaginal douching did not show indications of teratogenic effects (Czeizel 2004). However, this study did not identify the time of exposure or usage during pregnancy.

Pharmacokinetics and Serum Drug Concentrations

Renal excretion is a major pathway for the elimination of drugs and their metabolites. Therefore, impaired renal function may cause accumulation of drugs and metabolites in serum, thus increasing the risk of adverse drug effect. This may be particularly important for drugs that have active metabolites, such as procainamide and carba-mazepine. Moreover, other pathological conditions such as liver disease, congestive heart failure, and hypothyroidism may also decrease clearance of drugs. Drugs may also be excreted through other routes, such as biliary excretion. The factors that determine elimination of a drug through the biliary track include chemical structure, polarity, and molecular weight as well as active transport sites within the liver cell membranes for that particular drug. A drug excreted in bile may be reabsorbed from the gastrointestinal track or a drug conjugate may be hydrolyzed by the bacteria of the gut, liberating the original drug, which can return into the blood...

Susceptibility Factors

Underlying disease is probably one of the most complex risk factors. Although general anesthesia is potentially more hazardous in patients with underlying disease in general (94) or specifically suffering from intracardiac conduction disturbances (95), severe hypertension (96), hypothyroidism (97), or cancer (98), it is extremely difficult to provide clear-cut recommendations, because the relative severity of disease in a given patient and the patient's response to the pathological process needs to be taken into account while, for instance, thiopental

Therapeutic drug monitoring of digoxin

Digitalis glycosides have been in use in medicine over 200 years. The main pharmacological effects include a dose-dependent increase in myocardial contractility and a negative chronotropic action. Digitalis also increases the refractory period and decreases impulse velocity in certain myocardial tissue such as the atrioventricular (AV) node . The electrophysiological properties of digitalis are reflected in the ECG by shortening of the QT interval. Both digoxin and digitoxin have narrow therapeutic index thus, therapeutic drug monitoring is essential for achieving optimal efficacy as well as to avoid toxicity. The therapeutic range of digoxin usually is 0.8-2.0 ng mL, but there is a substantial overlap between therapeutic and toxic concentrations. Moreover, mild-to-moderate renal failure may also significantly increase the risk with digoxin therapy (1). Digoxin toxicity may occur with a lower digoxin level, if hypokalemia, hypomagnesemia, or hypothyroidism coexists. Likewise, the...

Thyroid Disorder and Drug Metabolism

Patients with thyroid disease may have an altered response to drugs. Thyroxin is a potent activator of the cytochrome P450 enzyme system, and hypothyroidism is associated with inhibition of hepatic oxidative metabolism of many drugs. Croxson et al. (82) measured serum digoxin concentration using a radioimmunoassay in 17 hyperthyroid and 16 hypothyroid patients and observed significantly lower levels of digoxin in patients with hyperthyroidism and significantly higher levels of digoxin in patients with hypothyroidism. Although there is a general conception that serum phenytoin clearance is not affected by thyroid function state, Sarich and Wright (83) reported a case where a 63-year-old female, who developed decreased serum level of free T4, showed phenytoin toxicity that may be related to decreased cytochrome P450-mediated hydroxylation of phenytoin. Another case report also indicated phenytoin intoxication induced by hypothyroidism. A 42-year-old woman with a 29-year history of...


Since the first reports of hypothyroidism, a number of studies have reported the occurrence of thyroid dysfunction in patients receiving aldesleukin alone or in combination with LAK cells, interferon alfa, interferon gamma, or tumor necrosis factor alfa (SED-13, 1104) (46). Symptoms were usually observed after 2-4 months of treatment (47-49), and mostly consisted of moderate hypothyroidism, which resolved after immunotherapy withdrawal or thyroxine treatment (49,50). Patients treated with aldesleukin plus interferon alfa more commonly developed biphasic thyroiditis with subsequent hypo-thyroidism or hyperthyroidism (50-53). of a favorable tumor response has been debated (47,49,54). The incidence of thyroid dysfunction did not correlate with the dose or the underlying disease, but increased with treatment duration (46). In a large survey of 281 cancer patients receiving low-dose (72 000 IU kg) or high-dose (720 000 IU kg) aldesleukin, up to 41 of previously euthyroid cancer patients...

Risk Factors

Taken lithium for an average of 54 months (mean serum concentration 0.42 mmol l), none became toxic and none had to stop treatment because of adverse effects. Transient renal function abnormalities were noted, one patient developed nephrogenic diabetes insipidus, and one became hypothyroid (78c). For lithium therapy in very old people the authors advised close monitoring in a specialized setting.

Lithium Augmentation

If augmentation is successful, it should be continued throughout the acute phase of treatment. This strategy can be limited by side effects and lithium's narrow therapeutic index. It is associated with hypothyroidism, tremor, increased thirst, increased urination, nausea, weight gain, and acne. Patients should be cautioned to avoid dehydration, which can precipitate toxic lithium blood levels.


Persons are supposed to avoid the drug if they suffer from low thyroid activity or enlarged prostate. Dipipanone can make people sleepy, and users are supposed to be cautioned about operating dangerous machinery. Volunteers in one experiment experienced lower alertness after taking dipi-panone, but other experiments found the substance to lack sedative action. Study does show that sedation can occur when dipipanone is given together with the antihistamine triprolidine. Dipipanone can cause headache, tremors, nausea, and vomiting, impair vision, interfere with breathing, make urination difficult, lower blood pressure, and reduce production of saliva. Seizures have been reported. Euphoria may occur. A case study notes delusions and hallucinations caused by the drug. Paranoia has occurred occasionally. A case report tells of serious colon difficulty occurring after someone injected three dissolved oral Diconal tablets, a combination product containing dipipanone and the...

Actions And Uses

Corticotropin is used for diagnostic testing of adreno-cortical function. This drug may also be used for the management of acute exacerbations of multiple sclerosis, non-suppurative thyroiditis, and hypercalcemia associated with cancer. It is also used as an anti-inflammatory and immunosuppressant drug when conventional glucocorti-coid therapy has not been effective (see Display 50-1).

Thyroid Hormones

AKA Cytomel, Dextrothyroxine, Eltroxin, Euthroid, Levoid, Levothroid, Levothyroxine, Levoxyl, Liotrix, Liothyronine, Proloid, Synthroid, Thyroglobulin, Thyroid, Thyrolar, Thyroxine. Effects A class of drugs that mimic the hormone produced in the thyroid gland. Subclinical hypothyroidism, or a slightly underfunctioning thyroid, can be one reason for poor concentration, mental confusion, and memory disturbances . The condition is also characterized by such symptoms as cold hands and feet, menstrual problems, dry skin, thin hair, and low energy levels. It is little-known and often overlooked by doctors.


Cally toward driving skills, however, led researchers to conclude that people should not operate a motor vehicle for 24 hours after an intramuscular injection of meperidine. Anyone with enlarged prostate, urinary difficulty, Addison's disease, or underactive thyroid should be wary about using the drug. An unusual case report tells of a patient developing Parkinson's disease symptoms from meperidine more commonly such reports arise from contaminated illicit substances related to meperidine. Another illicit peril occurs when persons grind up and inject oral meperidine tablets the talc in those tablets can block tiny blood vessels throughout the body and also cause those vessels to bleed serious business in the eyes or brain. Illicit intramuscular injection of the drug over a period of years can cause muscle damage. Injecting into an artery can lead to gangrene.

Xray examinations

These effects are a function of the dose administered and of the stage of development of the embryo. Embryo fetai death may also occur during the first 5 days after conception (i.e. in the all-or-none period ) the lowest lethal dose is 10 rads (0.1 Gy). During embryogenesis, the lowest lethal dose for the embryo increases to 25-50 rads and later to more than 100 rads (lGy) (Brent 1999). Severe CNS malformations are to be expected with exposures above 20 rads during early gestation (18-36 days after conception). Microcephaly and mental retardation were observed only after exposures above 20 rads between weeks 8 and 15 after conception. The conclusion from most studies is that for doses lower than 0.05 Gy (i.e. 5 rads) there is no significant increase of the malformation rate in humans, and the risk clearly is increased above 20-50 rads (Brent 1999. Sternberg 1973). A common and important finding is the absence of visceral, limb or other malformations unless there is...

Lithium Carbonate

Adverse effects may include hand tremor (counteracted by 10 - 20 mg of propranolol as needed), goitre or hypothyroidism (counteracted by the concurrent administration of thyroxine), lowered renal concentrating ability and polyuria, weight gain (which can be alleviated by moderate dieting, exercise), defecation urge and loose stools (reduction of dosage), and, in a few cases, memory impairment, and reduced reaction speed.


PRECAUTIONS Warnings Lithium toxicity can occur if the level of lithium is too high. Symptoms include tremor, nausea, vomiting, mental confusion, slurred speech, lack of coordination, and muscular weakness. Consult your physician and obtain a blood lithium level immediately if you suspect your lithium level is too high. Avoid dehydration, as lithium may rise to toxic levels. Use extra caution if you have Kidney or thyroid disease, as lithium can worsen disorders of either organ. Tests needed before starting Kidney and thyroid function tests. Some doctors recommend an EKG because lithium can cause changes in the EKG. Although this is insignificant to your health, it may impair the interpretation of the EKG if heart problems arise at a later date. Alcohol Should be avoided because it can worsen depression. Use in pregnancy When taken during the first trimester, lithium can cause a heart defect.


As well as nicotine and cotinine, other toxic and carcinogenic chemicals and cadmium (Radisch 1987) also appear in the milk of smokers (Radisch 1987). Among 50 smoking mothers, a lower iodine content of the milk was found compared to a control group of 90 non-smokers. According to the authors, this could cause iodine deficiency in the infants requiring supplementation (Laurbcrg 2004).

Drug Interactions

Lithium side-effects and predictors of hypothyroidism in patients with bipolar disorder sex differences. J Psychiatry Neurosci 2002 27 104-7. 26. Kupka RW, Nolen WA, Post RM, McElroy SL, Altshuler LL, Denicoff KD, Frye MA, Keck PE, Leverich GS, Rush AJ, Suppes T, Pollio C, Drex-hage HA. High rate of autoimmune thyroiditis in bipolar disorder lack of association with lithium exposure. Biol Psychiatry 2002 51 305-11. 31. Bermudes RA. Psychiatric illness or thyroid disease Don't be misled by false lab tests. Curr Psychiatry 2002 1 51-2, 57-61. 33. Obuobie K, Al-Sabah A, Lazarus JH. Subacute thyroiditis in an immunosuppressed patient. J En-docrinol Invest 2002 25 169-71.

Cleome gynandra L

Pharmaceutical interest The counter-irritant property of Cleome gynan-dra L. is attributed to glucosinolates. When the leaves of any glucosinolate-containing plant are bruised, glu-cosinolates are hydrolyzed by a p-thioglucosidase enzyme (myrosin) into a number of extremely reactive, volatile and pungent isothiocyanates, which cause skin tingling and rubefaction, and upon prolonged contact with the skin vesication (Fig. 119). In addition, isothiocyanates capture iodide and prevent its uptake by the thyroid resulting in hypothyroidism and goiter. Isothiocyanates occur in Brassica nigra (L.) Koch. (family Brassicaceae), which has been used since ancient times to make cataplasms. The therapeutic potential of Cleome gynandra L. is open for pharmacological exploration.

Types of Arrhythmias

Sinus bradycardia may occur with excessive vagal stimulation, deficient sympathetic tone, and sinus node dysfunction. It often occurs in healthy young adults, especially athletes and during sleep. Other conditions associated with sinus bradycardia include hypothyroidism, hypothermia, and drugs such as beta-blocker agents, amiodarone, diltiazem, and verapamil. A symptomatic sinus bradycardia does not require treatment. Acute, symptomatic sinus bradycardia can be treated with atropine or a temporary transvenous pacemaker. Chronic symptomatic sinus bradycardia (6,10) requires insertion of permanent pacemaker. The P, QRS, and T deflection (4,10) are all normal, but cardiac cycle duration (the PP interval) is altered.

Herbal Alert Ephedra

Many members of the Ephedra family have been used medicinally (ie, E. sinica and E. intermedia). Ephedra preparations have traditionally been used to relieve cold symptoms, improve respiratory function, as an adjunct in weight loss, and to treat a variety of conditions from headaches to sexually transmitted disease. Large doses may cause a variety of adverse reactions, such as hypertension, irregular heart rate, tremors, epigastric pain, nausea, vomiting, sweating, weakness, and possible dependence. Ephedra is contraindicated in patients with hypertension, glaucoma, hypertrophy of the prostate, urinary tract problems, clotting disorders, anxiety, anorexia, colitis, thyroid disease, or diabetes. Ephedra should not be used with the cardiac glycosides, halothane, guanethi-dine, MAOIs, oxytocin, and in patients taking St. John's wort. Weight loss preparations containing ephedra should be avoided.


The optimal dosage of levothyroxine should be based on repeated measurements of T3 and TSH serum concentrations. The daily recommended dose depends on the aim of the therapy. Thyroid replacement therapy for control of spontaneous or iatrogenic hypothyroidism should aim at a dosage of levothyroxine that maintains TSH concentrations within the low reference range. This will usually be associated with a free T4 concentration in the high reference range and a T3 concentration within the reference range. The mean requirement for such patients is As with all forms of long-term therapy, adherence to the prescribed dosage of levothyroxine is not always optimal, and an unwarranted fear of thyroid-induced osteoporosis can add to this lack of adherence. Inadequacy of thyroxine replacement therapy is not always easily recognized. Several patients were reported with clearly inadequate or excessive consumption of levothyroxine despite a correct prescription. All patients had depression, which could...


Although povidone-iodine is no longer used in dialy-sates, a povidone-iodine-containing cap is used to seal the Tenckhoff catheter during the day. Iodine-induced hypothyroidism occurred in a 3-year-old boy and an 18-month-old girl, in both cases due to the sealing cap (9). The povidone-iodine inside the cap diffused into the catheter and flushed into the peritoneal cavity at the next dialysis session.

Vitamin B12

Dilantin can deplete the body's stores of B-12, and an underactive thyroid gland can interfere with the absorption of this vitamin. It can also be destroyed or have absorption interfered with by acids and alkalies, alcohol, anticonvulsants, chloramphenicol, cholestyramine, cimetidine, coffee, colchicine, estrogen, famotidine, laxatives, neomycin, nizatidine, oral contraceptives, potassium (extended-release forms), ranitidine, sleeping pills, stomach medications (such as Prevacid, Prilosec, Pepcid, Tagamet, and Zantac), sunlight, tobacco, vitamin C (if taken within two hours of each other), and water. As it is only found in meat and dairy products, strict vegetarians may not get enough, though lack of deficiency in nonmeat eaters leads some to speculate that some vegetables may contain bacteria that produce B-12. The vitamin needs to be taken with calcium to be properly absorbed and utilized by the body.


PRECAUTIONS Warnings If you drink alcohol after taking it, acetaldehyde will build up, leading you to experience flushing, a headache, shortness of breath, nausea, vomiting, sweating, thirst, chest pain, rapid heart rate, agitation, and confusion. When severe, you may experience impairment of breathing and heart function, convulsions, and even death. The severity of the reaction is influenced by the amount of disulfiram and alcohol in your system. Don't use if you have Heart problems, as the disulfiram-alcohol reaction can place an extra strain on the heart. Use with extra caution if you have Diabetes, epilepsy, hypothyroidism, kidney or liver problems, as an accidental disulfiram-alcohol reaction may impair your health further. Tests needed before starting None.

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