Treatment of Cerebral Ischemia

Numerous studies on the effects of EGb on cerebral ischemia have been conducted over the course of many years. EGb has extensive protective effects on the central nervous system (CNS) and cerebrovascular system. It functions as a neuroprotective agent in its ability to eliminate free radicals, acts as an antioxidant and free-radical scavenger, reduces lipid peroxidation, and is a membrane stabilizer and inhibitor of platelet-activating factor via the terpene ginkgolide B [8]. Different pathological models of cerebral ischemia were used to evaluate its effects, and measurements were taken at both the cellular and molecular levels to determine its mechanisms of action, which depend on a direct effect on neuronal cells and an indirect effect on brain circulation. In experimental models with different paradigms such as focal and global ischemia, administrated before or after the insult and given oraly or intraperitoneally [9-12], in oedema and hypoxia, it was mostly shown that EGb reduced vascular, tissue and metabolic disturbances as well as their neurological behavioural consequences. In general, in experimentally induced cerebral ischemia (MCAO), a 7-d treatment with EGb reduced the volume of CNS damage [13, 14], protected against neuronal death in the hippocampal CA1 area of the gerbil brain and extended protection to cells in the frontal lobe [15, 16].

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Traditional Chinese Medicine

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