Transcription Factors

Curcumin may operate through suppression of various transcription factors, including nuclear factor-kappa B (NF-kB), signal transducer and activator of transcription 3 (STAT3), early growth response protein 1, activator protein 1 (AP-1), peroxisome proliferators-activated receptor gamma (PPAR-y), and P-catenin [13, 14, 19]. These transcription factors play essential roles in various diseases. The constitutively active form of NF-kB has been reported in a wide variety of cancers. NF-kB is required for the expression of genes involved in cell proliferation, cell invasion, metastasis, angiogenesis, and resistance to chemotherapy. Bharti et al. demonstrated that curcumin inhibited IL-6-induced STAT3 phosphorylation and consequent STAT3 nuclear translocation [20]. Activation of PPAR-y inhibits the proliferation of nonadipocytes. Xu et al. demonstrated that curcumin dramatically induced expression of the PPAR-y gene and activated PPAR-y [21]. AP-1, another transcription factor that has been closely linked with proliferation and transformation of tumor cells, has been shown to be suppressed by curcumin. Studies also suggest that curcumin has a potential therapeutic effect on prostate cancer cells through down-regulation of AR and AR-related cofactors [13].

Was this article helpful?

0 0
Traditional Chinese Medicine

Traditional Chinese Medicine

Ever wondered what Chinese medicine is all about and whether it works? Thinking about consulting a practitioner but want to know some facts first? Look no further! Here's your chance to purchase an in depth and fully comprehensive eBook on anything and everything to do with this ancient philosophy.

Get My Free Ebook


Post a comment