Shengmai San (SMS) is a composite formula comprising three component herbs, Ginseng Radix, Ophiopogon Radix, and Schisandrae Fructus. It has been extensively used for treating cardiac disorders. Pretreatment with SMS reduced hydrogen peroxide-induced PC12 cell death [208]. SMS inhibits cerebral oxidative damage after forebrain ischemia-reperfusion in the rat [175]. The injection of SMS directly into duodenum 2 h before cerebral ischemia reduced TBARS in the bilateral carotid artery occlusion rat model. SMS also suppressed TBARS formation even when it was administered after 45min of reperfusion following ischemia [209, 211]. These findings suggest that SMS improves the oxidative damage and thus protects against cell death in the brain ischemia rat model.

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