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Down-regulation of epidermal growth factor receptor (EGFR)-1 and EGFR-2 (also called HER2/neu) activity represents one possible mechanism by which curcumin suppresses the growth of breast cancer cells. Almost 30% of breast cancer cases overexpress the HER2/neu proto-oncogene [15], and both HER2 and EGF receptors stimulate proliferation of breast cancer cells. Overexpression of these two proteins correlates with progression of human breast cancer and poor patient prognosis [15]. Curcumin has been shown to down-regulate the activity of EGFR [16,17] and HER2/neu [16, 17] and to deplete the cells of the HER2/neu protein [18].

Prostate cancer cell lines LNCaP and PC-3 were treated with curcumin, and its effects on signal transduction and expression of androgen receptor (AR) and AR-related cofactors were analyzed. The results showed that curcumin down-regulated transactivation and expression of AR and CREB (cAMP response element-binding protein-binding protein. It also inhibited the transforming activities of both cell lines as evinced by reduced colony-forming ability in soft agar. These findings suggest that curcumin has a potential therapeutic effect on prostate cancer cells through down-regulation of AR and AR-related cofactors [18].

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10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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