The roots of Pueraria thunbergiana Benth. (Legumnosae) are widely used in TEM for moderating alcohol abuse, for hypotensive, antipyretic, and analgesic effects, and for treatment of the common cold. Puerarin (Fig. 16.1), daidzin, and daidzein are three of the major isoflavonoid compounds isolated from the extract of P. lobata. P. lobata flavonoids increase the cerebral blood flow of anesthetized mice  and reduce the infarct volume in MCAo by increasing the activities of SOD . Their isoflavonoids have potent inhibitory effects on PGE2 production , and the an-tioxidant effect, partly dependent on free-radical scavenging, antilipid peroxidation, and enhancement of SOD activity .
Isoflavones in plants are known to have an estrogenic action. Puerarin has protective effects on cultured mouse cerebral cortical neurons damaged by Glu, NMDA, or KA . Puerarin also shows neuroprotective effects in MCAo rats . Puerarin clearance in normal rats was much faster than that in cerebral ischemia-reperfusion rats induced by MCAo and BCAo . Genistein, a PTK inhibitor, prevented the increase of p-STAT3 and DNA binding activity in ischemic reperfusion injury at 4-VO . It also prevented gerbil transient ischemia via a decrease in tyrosine phosphorylation of NR2B .
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