Curcumin suppresses a number of protein kinases, including mitogen activated protein kinase (MAPK), Jun N-terminal kinase, protein kinase A (PKA), protein kinase C (PKC), src tyrosine kinase, phosphorylase kinase, IKBa kinase, janus ki-nase (JAK), and the growth factor receptor protein tyrosine kinases. Treatment with curcumin inhibited highly purified PKA, PKC, protamine kinase, phosphorylase kinase, autophosphorylation-activated protein kinase, and pp60c-src tyrosine kinase . Phorbol-myristate-acetate-induced activation of cellular PKC is suppressed by curcumin . Treatment of cells with curcumin inhibited tetradecanoylphorbol-acetate-induced PKC activity without affecting the level of PKC. Curcumin inhibited the PKC activity in vitro as well as in the cells .
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