Cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) are important enzymes that mediate inflammation through production of prostaglandins and leukotrienes, respectively. Curcumin has been shown to suppress the expression of both COX-2 and LOX proteins as well as their enzymatic activities, most likely through the down-regulation of NF-kB, which is needed for COX-2 expression. Several groups have shown that curcumin down-regulates the expression of COX-2 protein in various tumor cells [22, 23]. Chun et al. reported that curcumin inhibited phorbol-ester-induced expression of COX-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kB activation . Plummer et al. measured COX-2 protein induction and prostaglandin E2 production in human blood after incubation with lipopolysaccharide. When 1 |M curcumin was added in vitro to blood from healthy volunteers, lipopolysaccharide-induced COX-2 protein levels and concomitant prostaglandin E2 production were reduced by 24% and 41%, respectively .
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Do You Suffer From the Itching and Scaling of Psoriasis? Or the Chronic Agony of Psoriatic Arthritis? If so you are not ALONE! A whopping three percent of the world’s populations suffer from either condition! An incredible 56 million working hours are lost every year by psoriasis sufferers according to the National Psoriasis Foundation.