Proinflammatory Enzymes

Cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) are important enzymes that mediate inflammation through production of prostaglandins and leukotrienes, respectively. Curcumin has been shown to suppress the expression of both COX-2 and LOX proteins as well as their enzymatic activities, most likely through the down-regulation of NF-kB, which is needed for COX-2 expression. Several groups have shown that curcumin down-regulates the expression of COX-2 protein in various tumor cells [22, 23]. Chun et al. reported that curcumin inhibited phorbol-ester-induced expression of COX-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kB activation [24]. Plummer et al. measured COX-2 protein induction and prostaglandin E2 production in human blood after incubation with lipopolysaccharide. When 1 |M curcumin was added in vitro to blood from healthy volunteers, lipopolysaccharide-induced COX-2 protein levels and concomitant prostaglandin E2 production were reduced by 24% and 41%, respectively [25].

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Natural Treatments For Psoriasis

Natural Treatments For Psoriasis

Do You Suffer From the Itching and Scaling of Psoriasis? Or the Chronic Agony of Psoriatic Arthritis? If so you are not ALONE! A whopping three percent of the world’s populations suffer from either condition! An incredible 56 million working hours are lost every year by psoriasis sufferers according to the National Psoriasis Foundation.

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