The root bark of Paeonia suffruticosa Andrews (Ranunculaceae) is a drug used in TEM as both an analgesic and an anti-inflammatory agent , and it is prescribed in various TEM preparations for the treatment of blood stagnation. It has been reported to have strong superoxide and hydroxyl radical scavenging activity . Its antioxidative effects are due to enhancing activities of SOD, CAT, and GPX . Paeonol (Fig. 16.1) inhibits cerebral ischemic injury by blocking increases in Ca2+, decreases in SOD activity and the content of MDA, and improved Ca2+-ATPase activity in ischemic brain tissue [121, 122]. a-benzoyloxypaeoniflorin, an antioxidant monoterpene glycoside, from P. suffruticosa has potent radical-scavenging activity on the DPPH radical .
The root of P. lactiflora Palla has long been used to treat abdominal pain and blood deficiencies in TEM. The oral administration of P. lactiflora extract and paeoniflorin, a major constituent of peony root, attenuated spatial cognitive deficits caused by scopolamine in rats . Paeoniflorin reduces the infarct volume as well as ameliorates the deficits in neurological symptoms caused by tMCAo in rats . Paeoniflorin ameliorates memory disruption mediated by adenosine A1 receptor in rodents .
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