Multiple Sclerosis

Reverse MS Now

Multiple Sclerosis Cure Diet

Get Instant Access

Multiple sclerosis is characterized by the destruction of oligodendrocytes and myelin sheath in the central nervous system (CNS). Curcumin inhibits experimental allergic encephalomyelitis (EAE), a model for multiple sclerosis, by blocking IL-12 signaling in T cells, suggesting that it would be effective in the treatment of multiple sclerosis. Natarajan and Bright investigated the effect of curcumin on the pathogenesis of CNS demyelination in EAE [74]. In vivo treatment of SJL/J mice with curcumin significantly reduced the duration and clinical severity of active immunization and adoptive transfer in EAE [74]. Curcumin inhibited EAE in association with a decrease in IL-12 production from macrophage/microglial cells and differentiation of neural antigen-specific Th1 cells. In vitro treatment of activated T cells with curcumin inhibited IL-12-induced tyrosine phosphorylation of Janus kinase 2, tyrosine kinase 2, and STAT3 and STAT4 transcription factors. Inhibition of the Janus kinase-STAT pathway by curcumin resulted in a decrease in IL-12-induced T-cell proliferation and Th1 differentiation. These findings show that curcumin inhibits EAE by blocking IL-12 signaling in T cells and suggest a rationale for its use in the treatment of multiple sclerosis and other Th1 cell-mediated inflammatory diseases.

Verbeek and coworkers examined the effects of curcumin on autoimmune T-cell reactivity in mice and on the course of EAE. Continuous oral administration of curcumin significantly affected antigen-specific proliferation and interferon-gamma production by lymph node-derived T cells following immunization with an EAE-inducing peptide [75]. The overall effects of oral curcumin were mild but beneficial.

Was this article helpful?

0 0
Traditional Chinese Medicine

Traditional Chinese Medicine

Ever wondered what Chinese medicine is all about and whether it works? Thinking about consulting a practitioner but want to know some facts first? Look no further! Here's your chance to purchase an in depth and fully comprehensive eBook on anything and everything to do with this ancient philosophy.

Get My Free Ebook


Post a comment