Multidrug resistance is a phenomenon that often is associated with enhanced drug efflux and thus decreased intracellular drug accumulation in tumor cells. It often is related to overexpression of P-glycoprotein on the surface of tumor cells, which reduces drug cytotoxicity. Curcumin has been shown to suppress the overexpression of P-glycoprotein in the multidrug-resistant human cervical carcinoma cell lines . Curcumin also down-regulates drug resistance by inhibiting expression of the mdr gene, which is responsible for this phenomenon .
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Do You Suffer From the Itching and Scaling of Psoriasis? Or the Chronic Agony of Psoriatic Arthritis? If so you are not ALONE! A whopping three percent of the world’s populations suffer from either condition! An incredible 56 million working hours are lost every year by psoriasis sufferers according to the National Psoriasis Foundation.