In Vivo Analgesic Effects of Hp Extracts and Harpagoside

The analgesic properties of Hp have been demonstrated in several studies using various models. Two studies using the writhing test reported significant analgesic effects after intraperitoneal administration of aqueous extracts [20,23], whereas only slight analgesic effects were reported with the same model for both aqueous and methano-lic extracts by Erdos and colleagues [24]. In the Randall-Soletto test, a 60% aqueous ethanol extract administered intraperitoneally exerted a dose-dependent analgesic effect. The extract (200 mg/kg) was significantly more effective than the comparator drug, diclofenac (80 mg/kg) [19]. In a heat-induced pain model, an aqueous methanolic extract of Hp exerted analgesic effects [24]. Intraperitoneal harpagoside exhibited analgesic effects in the rabbit ear model [17].

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