The analgesic properties of Hp have been demonstrated in several studies using various models. Two studies using the writhing test reported significant analgesic effects after intraperitoneal administration of aqueous extracts [20,23], whereas only slight analgesic effects were reported with the same model for both aqueous and methano-lic extracts by Erdos and colleagues . In the Randall-Soletto test, a 60% aqueous ethanol extract administered intraperitoneally exerted a dose-dependent analgesic effect. The extract (200 mg/kg) was significantly more effective than the comparator drug, diclofenac (80 mg/kg) . In a heat-induced pain model, an aqueous methanolic extract of Hp exerted analgesic effects . Intraperitoneal harpagoside exhibited analgesic effects in the rabbit ear model .
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