Huanglianjiedu decoction (HLD), which consists of four herbs, Coptidis Rhizoma, Scutellariae Radix, Phellodendri Cortex, and Gardeniae Fructus, has been used in TEM as a therapy for various clinical symptoms associated with gastrointestinal disorders, inflammation, and cardiovascular diseases. These four herbs have been the subject of many investigations on the neuroprotective effects of HLD.
Chronic oral pre- and post-HLD prevented cholinergic synaptic dysfunction and serotonergic presynaptic hyperactivity induced by transient ischemia . Pre-treatment with oral administration of HLD protected against the impairment of learning and memory induced by transient cerebral ischemia and prevented a decrease in the ACh content of the mouse brain . HLD also protected against transient forebrain ischemia induced by occlusion of both common carotid arteries in C57BL/6 mice by increasing the expression of Cu/Zn-SOD and reducing the exposure of hippocampal neurons to oxidative stress . HLD extract reduced ischemia-reperfusion brain injury and neutrophil infiltration in MCAo rats . The neuroprotective effect of HLD can be explained by multiple mechanisms, the anti-inflammatory and antioxidant activity of Scutellariae Radix, Coptidis Rhizoma, and Gardiniae Fructus, and inhibition of ACh release by Coptidis Rhizoma and Phel-lodendri Cortex.
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