Bombycis Corpus

Bombycis Corpus (BC) is a Bombyx mori larva (silk moth larva, Bombycidae) killed by infecting with the fungus B. bassiana. It has been used in TEM to treat palsy, headache, convulsion, and speech problems induced by stroke and tremor.

Several sterols have been isolated from BC. BC has a protective effect against A ¡5 -induced cytotoxicity in cultured astrocyte cells through the inhibition of lipid peroxidation and protection of antioxidative enzymes such as catalase, SOD, GSH-Px, and glutathione-S transferase [127]. Sphingolipids from BC also have neurotrophic effects as shown by examining PC12 cell neurite outgrowth [128]. Pretreatment with BC protected primary hippocampal cultures from embryonic day 18 embryos against NMDA-induced toxicity [129]. BC contributes to protect human brain by inhibiting the release of glutamate.

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