Kalina Duszka, Brian F.C. Clark, Frank Massino and Jan Barciszewski
Abstract Kinetin (N6-furfuryladenine) is a cytokinin growth factor with several biological effects observed for human cells and fruit flies. It was given the name kinetin because of its ability to induce cell division. Kinetin is often used in plant cell and tissue culture for induction of callus formation (in conjunction with auxin) and to regenerate shoots from callus (with lower auxin concentration). Kinetin exists naturally in the DNA of almost all organisms tested so far, including human cells, and various plants. The mechanism of kinetin synthesis in DNA is thought to be via the production of furfural, an oxidative damage product of DNA deoxyribose, and it is quenched by the adenine base converting it into N6-furfuryladenine. Since 1994 kinetin has been thoroughly tested for its powerful antiaging effects in human skin cells and other systems. At present, kinetin is one of the most widely used components in numerous skin care cosmetics and cosmeceuticals. There are some reports published on other biological effects of kinetin in human beings, as an antiplatelet aggregation factor reducing thrombus formation, and its ability to correct genetic diseases of RNA missplicing. Kinetin was shown to be more effective in the improvement of skin texture, making it smoother and with a significant reduction in fine lines and wrinkles. It is a stable antioxidant that slows down the aging process.
Keywords cytokinins • kinetin • DNA damage • biological activity • antiaging
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