Angelicae Radix has been used as a sedative or a tonic and to treat disorders of menstruation in women, anemia, and menopause syndrome. Angelica gigas Nakai (Um-bellaceae) is used in Korea, and A. sinensis (Oliv.) Diels is used in China. A. gigas includes decursin, decursinol angelate, angelan, and decursinol. A. gigas protects mice against AP-induced memory impairment . A. gigas has antinociceptive effects on pain responses induced by TNF-a, IFN-y, IL-1P, glutamate, NMDA, or kainic acid . Decursin ameliorates scopolamine-induced memory impairment in mice . Decursinol and decursin protect primary cultured rat cortical cells against glutamate-induced oxidative stress by both reducing calcium influx and acting on the cellular antioxidative defence system .
A. sinensis contains ferulic acid, ligustilide, angelicide, brefeldin A, butyli-denephthalide, butyphthalide, succinic acid, nicotinic acid, uracil, and adenine. Extracts of A. sinensis showed a scavenging effect on peroxide and hydroxyl radicals and inhibited lipid peroxidation of the liver . A. sinensis protects the brain from damage induced by transient forebrain ischemia in mice . A. sinensis extract also has attenuating effects on amnesia induced by various drugs related to memory processes .
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