The expression of various cell surface adhesion molecules such as intercellular cell adhesion molecule 1, vascular cell adhesion molecule 1, and endothelial leukocyte adhesion molecule 1 on endothelial cells is absolutely critical for tumor metastasis . Curcumin inhibits inflammation by blocking the adhesion of monocytes to endothelial cells by inhibiting activation of these cell adhesion molecules. The expression of these molecules is in part regulated by NF-kB . We have shown that treatment of endothelial cells with curcumin blocks the cell surface expression of adhesion molecules, and this accompanies the suppression of tumor cell adhesion to endothelial cells . We also have demonstrated that down-regulation of these adhesion molecules is mediated through down-regulation of NF-kB activation . Gupta and Ghosh reported that curcumin inhibits TNF-induced expression of adhesion molecules on human umbilical vein endothelial cells . Jaiswal et al. showed that curcumin treatment causes p53- and p21-independent G2/M phase arrest and apoptosis in colon cancer cell lines . Their results suggest that curcumin treatment impairs both Wnt signaling and cell-cell adhesion pathways, resulting in G2/M phase arrest and apoptosis in HCT-116 cells.
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Do You Suffer From the Itching and Scaling of Psoriasis? Or the Chronic Agony of Psoriatic Arthritis? If so you are not ALONE! A whopping three percent of the world’s populations suffer from either condition! An incredible 56 million working hours are lost every year by psoriasis sufferers according to the National Psoriasis Foundation.