Tolerance to Hallucinogens

As the body becomes tolerant to the effects of a drug, users need to take ever-increasing quantities of the substance to achieve the same effects experienced at lower doses. This is why tolerance is such an important characteristic of dependence on certain drugs.

Multiple studies have shown that tolerance to hallucinogens such as LSD, mescaline, psilocybin, and psilocin builds very quickly; after three to four days of drug taking, the user does not experience any psychedelic effect regardless of the dose of the drug. Researchers have also discovered that once tolerance to these hallucinogens has been achieved, the user only has to abstain from the drug for about four days to once again experience the full effect of the hallucinogen. Experts therefore agree that tolerance-driven dependency upon these drugs is virtually unknown since tolerance tends to limit the frequency of their use.

MDMA is rather unique in this group of hallucinogens with regard to tolerance, and, to some extent, dependency. Tolerance to the euphoric sensations from Ecstasy develops quickly in a fashion similar to other hallucinogens. As a result, users sometimes take escalating doses of the drug to prolong their pleasant effects (called "stacking"). However, as tolerance builds, increased use of MDMA results in an escalation of the more stimulating aspects of the drug (described as "unpleasant") along with a decrease in the euphoria and openness associated with Ecstasy. Users also report combining alcohol, marijuana, or other drugs with these stacked doses of MDMA. Researchers and physicians cite evidence that many of these accelerated efforts to sustain a good trip with MDMA can pose unpredictable physical and psychological dangers to the user, and more often than not result in a bad trip.

Interestingly, when users are tolerant to LSD, they also become tolerant to mescaline and psilocybin as well. This is called cross-tolerance—one becomes tolerant to the effects of all hallucinogens simply by taking one frequently. It is unclear whether MDMA is cross-tolerant with any other hallucinogens. Its structural and chemical similarity to mescaline leads some researchers to conclude that MDMA may very well be cross-tolerant with these other hallucinogens. However, other researchers disagree and base their hypothesis on evidence that there is no cross-tolerance between LSD (and other related hallucinogens) and non-hallucinogenic amphetamines. Since MDMA is an amphetamine derivative, these researchers conclude that MDMA cannot be cross-tolerant with the other hallucinogens.

Continue reading here: Agonists And Antagonists

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  • feorie
    Does taking lsd increase tolorance to psylycybin mushrooms?
    2 months ago
  • Kenneth
    How fast does your body build up a tolerance to psilocybin?
    5 months ago
    How can you lower your tolerance to psilocybin?
    8 months ago
  • Max Strauss
    Can you build up on psylocybin?
    11 months ago
    How quickly does toletance to psilocybin build up?
    11 months ago
    How fast is psilocybin tolerance?
    1 year ago
    How often can you do hrooms?
    1 year ago
  • adalberto
    Are acid and shrooms the same tolerance?
    1 year ago
  • rachele
    Does your tolerance immediate lower when eating musbrooms?
    1 year ago
  • joshua
    Do people decelop a tolerance for psylocibin?
    1 year ago
  • leah
    Is there a cross tolerance for mdma and lsd?
    1 year ago
  • george sun
    How long after lsd does a tolerance build?
    1 year ago
  • guido
    How fast can you build up a tolerance to acid?
    1 year ago
  • thorsten
    Can you build a tolerance to psylocibin?
    1 year ago
  • Christina
    How to lose lad tolerance?
    1 year ago
  • bruno
    How quick does tolerance build psilocybin?
    1 year ago
  • Rudibert
    Can i take shrooms multiple days?
    1 year ago
  • roisin
    Do you develop a tolerence to mushrooms?
    1 year ago
    Does shrooms have cross tolerance with molly?
    1 year ago
  • alexandra
    Are psychedelic tolerance different?
    1 year ago
  • Aman
    How often can you do shrooms without getting a tolerance?
    1 year ago
  • isa
    How long does tolerance to psylocibin last?
    1 year ago
  • stefan
    Do mushrooms build up tolerance for lsd?
    1 year ago
  • nicola
    Do shrooms affect tolerence to lsd?
    1 year ago
  • anu
    Can u bild up a roleramce to shrooms?
    1 year ago