References

McGrath MS, etal. (1989) Proceedings of the National Academy of Sciences, USA, April 15,1989.

Takemoto DJ, etal. (1998) Anticancer Res 18(1A): 357-361.

Mi SL, etal. (2005) Archives of Biochemistry and Biophysics (43)2, 15: 258-265.

Warning: Side effects of trichosanthin observed during clinical trials include allergic reactions, neurotoxic effect and flu-like symptoms. Among them, the most dangerous complication seen with the drug is anaphylactic shock, a sudden, severe life-threatening allergic reaction that can kill within days. This reaction was experienced by 10-20 percent of people using the drug. Therefore, it is critical to modify the molecular structure of trichosanthin in order to decrease its side effects.

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